MSL10 mechanosensitive channel of small conductance-like 10 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MSL10
Official Full Name: mechanosensitive channel of small conductance-like 10
Primary source: TAIR:AT5G12080
Locus tag: AT5G12080
See related: Araport:AT5G12080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATMSL10; F14F18.230; F14F18_230; mechanosensitive channel of small conductance-like 10
Summary: Encodes a mechanosensitive (or stretch-activated) ion channel in the plasma membrane with a moderate preference for anions.
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Genomic context

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See MSL10 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 8

Sequence:: Chromosome: 5; NC_003076.8 (3897893..3901790, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Open structure and gating of the Arabidopsis mechanosensitive ion channel MSL10.
Title: Open structure and gating of the Arabidopsis mechanosensitive ion channel MSL10.
The Mechanosensitive Ion Channel MSL10 Modulates Susceptibility to Pseudomonas syringae in Arabidopsis thaliana.
Title: The Mechanosensitive Ion Channel MSL10 Modulates Susceptibility to Pseudomonas syringae in Arabidopsis thaliana.
Interactions between the N- and C-termini of the mechanosensitive ion channel AtMSL10 are consistent with a three-step mechanism for activation.
Title: Interactions between the N- and C-termini of the mechanosensitive ion channel AtMSL10 are consistent with a three-step mechanism for activation.
Studies provide evidence that MSL10 and DEK1 are associated with two distinct mechanosensitive (MS) channel activities. MSL10 mediates large fluxes of anions while DEK1 mediates small fluxes of calcium. MSL10 and DEK1 encode bifunctional proteins whose cytosolic domain functioning differently from the MS channel. [review]
Title: Sensing and transducing forces in plants with MSL10 and DEK1 mechanosensors.
results suggest that MSL10 is involved in the wound-triggered early signal transduction pathway and possibly in regulating the positive feedback synthesis of JA.
Title: A gain-of-function mutation in Msl10 triggers cell death and wound-induced hyperaccumulation of jasmonic acid in Arabidopsis.
The plant-specific N-terminal domain of MSL10 is capable of inducing cell death, this activity is regulated by phosphorylation, and MSL10 has two separable activities-one as an ion channel and one as an inducer of cell death.
Title: Arabidopsis MSL10 has a regulated cell death signaling activity that is separable from its mechanosensitive ion channel activity.
MSL10 demonstrated asymmetric activation/inactivation kinetics, with the channel closing at substantially lower tensions than channel opening.
Title: MscS-Like10 is a stretch-activated ion channel from Arabidopsis thaliana with a preference for anions.
MSL9 and MSL10 are required for mechanosensitive channel activities detected in protoplasts derived from root cells. [MSL10]
Title: Two MscS homologs provide mechanosensitive channel activities in the Arabidopsis root.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001125740.2

Supported by ESTs:

NM_121246.5

Supported by ESTs:

NM_180479.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables mechanosensitive monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables mechanosensitive monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within detection of mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic anion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within programmed cell death in response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mechanosensitive channel of small conductance-like 10

NP_001119212.1

mechanosensitive channel of small conductance-like 10 (MSL10); FUNCTIONS IN: mechanically-gated ion channel activity; INVOLVED IN: detection of mechanical stimulus; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Membrane protein, At2g17000, predicted (InterPro:IPR016688), Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920), Mechanosensitive ion channel MscS (InterPro:IPR006685); BEST Arabidopsis thaliana protein match is: mechanosensitive channel of small conductance-like 9 (TAIR:AT5G19520.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_196769.1

mechanosensitive channel of small conductance-like 10 (MSL10); FUNCTIONS IN: mechanically-gated ion channel activity; INVOLVED IN: detection of mechanical stimulus; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Membrane protein, At2g17000, predicted (InterPro:IPR016688), Mechanosensitive ion channel MscS (InterPro:IPR006685), Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920); BEST Arabidopsis thaliana protein match is: mechanosensitive channel of small conductance-like 9 (TAIR:AT5G19520.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NP_850810.1

mechanosensitive channel of small conductance-like 10 (MSL10); FUNCTIONS IN: mechanically-gated ion channel activity; INVOLVED IN: detection of mechanical stimulus; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Membrane protein, At2g17000, predicted (InterPro:IPR016688), Like-Sm ribonucleoprotein (LSM)-related domain (InterPro:IPR010920), Mechanosensitive ion channel MscS (InterPro:IPR006685); BEST Arabidopsis thaliana protein match is: mechanosensitive channel of small conductance-like 9 (TAIR:AT5G19520.1); Has 3162 Blast hits to 3155 proteins in 988 species: Archae - 147; Bacteria - 2129; Metazoa - 0; Fungi - 206; Plants - 206; Viruses - 0; Other Eukaryotes - 474 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

3897893..3901790 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001125740.2 → NP_001119212.1 mechanosensitive channel of small conductance-like 10 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

C0Z2U6, Q9LYG9

UniProtKB/TrEMBL

A0A178U9L6, A0A5S9Y3H0

Conserved Domains (1) summary

cl39057
Location:516 → 720

MS_channel; Mechanosensitive ion channel
NM_121246.5 → NP_196769.1 mechanosensitive channel of small conductance-like 10 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

C0Z2U6, Q9LYG9

UniProtKB/TrEMBL

A0A178U9L6, A0A5S9Y3H0

Conserved Domains (1) summary

cl39057
Location:516 → 720

MS_channel; Mechanosensitive ion channel
NM_180479.2 → NP_850810.1 mechanosensitive channel of small conductance-like 10 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

C0Z2U6, Q9LYG9

UniProtKB/TrEMBL

A0A178U9L6, A0A5S9Y3H0

Conserved Domains (1) summary

cl39057
Location:516 → 720

MS_channel; Mechanosensitive ion channel