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    Eml2 echinoderm microtubule associated protein like 2 [ Mus musculus (house mouse) ]

    Gene ID: 72205, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eml2provided by MGI
    Official Full Name
    echinoderm microtubule associated protein like 2provided by MGI
    Primary source
    MGI:MGI:1919455
    See related
    Ensembl:ENSMUSG00000040811 AllianceGenome:MGI:1919455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EMAP-2; 1600029N02Rik
    Summary
    Predicted to enable ionotropic glutamate receptor binding activity and microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; negative regulation of microtubule polymerization; and regulation of microtubule nucleation. Predicted to be located in cytoplasm and microtubule. Predicted to colocalize with mitotic spindle. Is expressed in genitourinary system; gut gland; heart; nervous system; and retina. Orthologous to human EML2 (EMAP like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 25.4), cortex adult (RPKM 23.5) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Eml2 in Genome Data Viewer
    Location:
    7 A3; 7 9.46 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18910322..18940407)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19176421..19206482)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1081 Neighboring gene small nuclear ribonucleoprotein D2 Neighboring gene gastric inhibitory polypeptide receptor Neighboring gene microRNA 330 Neighboring gene VISTA enhancer mm1753 Neighboring gene G protein-coupled receptor 4 Neighboring gene optic atrophy 3 Neighboring gene STARR-positive B cell enhancer ABC_E3702 Neighboring gene predicted gene, 25134

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ionotropic glutamate receptor binding  
    enables microtubule binding  
    enables microtubule binding  
    enables microtubule binding  
    enables tubulin binding  
    enables tubulin binding  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in microtubule  
    colocalizes_with mitotic spindle  
    colocalizes_with mitotic spindle  
    colocalizes_with mitotic spindle  

    General protein information

    Preferred Names
    echinoderm microtubule-associated protein-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162996.2NP_001156468.1  echinoderm microtubule-associated protein-like 2 isoform 2

      See identical proteins and their annotated locations for NP_001156468.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 3. These differences cause translation initiation at a novel AUG and result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 3.
      Source sequence(s)
      AC145199
      Consensus CDS
      CCDS85224.1
      UniProtKB/Swiss-Prot
      E9QK48, Q7TNG5, Q9DAS8
      Related
      ENSMUSP00000112447.3, ENSMUST00000120595.8
      Conserved Domains (4) summary
      COG2319
      Location:76497
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:1991
      HELP; HELP motif
      sd00039
      Location:297335
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:348647
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001347582.2NP_001334511.1  echinoderm microtubule-associated protein-like 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AC145199
      Consensus CDS
      CCDS85223.1
      UniProtKB/TrEMBL
      E9QK48
      Related
      ENSMUSP00000112491.2, ENSMUST00000117338.8
    3. NM_028153.2NP_082429.1  echinoderm microtubule-associated protein-like 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding region, compared to variant 3. These differences cause translation initiation at a novel AUG and result in an isoform (1) with a shorter and distinct N-terminus, compared to isoform 3.
      Source sequence(s)
      AC145199
      Consensus CDS
      CCDS52055.1
      UniProtKB/Swiss-Prot
      Q7TNG5
      Related
      ENSMUSP00000037654.9, ENSMUST00000048502.10
      Conserved Domains (4) summary
      COG2319
      Location:95516
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:19110
      HELP; HELP motif
      sd00039
      Location:316354
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:367666
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      18910322..18940407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250714.3XP_011249016.1  echinoderm microtubule-associated protein-like 2 isoform X1

      Conserved Domains (4) summary
      COG2319
      Location:267688
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:401438
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:210282
      HELP; HELP motif
      cl29593
      Location:695840
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_011250715.2XP_011249017.1  echinoderm microtubule-associated protein-like 2 isoform X2

      Conserved Domains (5) summary
      COG2319
      Location:222643
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:356393
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:165237
      HELP; HELP motif
      cl01090
      Location:1469
      SlyX
      cl29593
      Location:650795
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_030243010.1XP_030098870.1  echinoderm microtubule-associated protein-like 2 isoform X4

      Conserved Domains (3) summary
      COG2319
      Location:22381
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:181219
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:302532
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_011250719.2XP_011249021.1  echinoderm microtubule-associated protein-like 2 isoform X3

      See identical proteins and their annotated locations for XP_011249021.1

      Conserved Domains (4) summary
      COG2319
      Location:61482
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:282320
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:476
      HELP; HELP motif
      cl29593
      Location:489634
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_011250718.3XP_011249020.1  echinoderm microtubule-associated protein-like 2 isoform X3

      See identical proteins and their annotated locations for XP_011249020.1

      Conserved Domains (4) summary
      COG2319
      Location:61482
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:282320
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:476
      HELP; HELP motif
      cl29593
      Location:489634
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_001778001.3 RNA Sequence

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