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    DIT2 putative cytochrome P450 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852011, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DIT2
    Official Full Name
    putative cytochrome P450
    Primary source
    SGD:S000002810
    Locus tag
    YDR402C
    See related
    AllianceGenome:SGD:S000002810; FungiDB:YDR402C; VEuPathDB:YDR402C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CYP56
    Summary
    Enables NADPH dehydrogenase activity. Involved in ascospore wall assembly. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 5. Orthologous to human CYP4F22 (cytochrome P450 family 4 subfamily F member 22). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DIT2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1272234..1273703, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hypoxanthine phosphoribosyltransferase Neighboring gene trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase Neighboring gene Dit1p Neighboring gene DNA-directed RNA polymerase II subunit RPB7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of two developmentally regulated genes involved in spore wall maturation in Saccharomyces cerevisiae. Briza P, et al. Genes Dev, 1990 Oct. PMID 2249774
    2. Gene expression from random libraries of yeast promoters. Ligr M, et al. Genetics, 2006 Apr. PMID 16415362, Free PMC Article
    3. An Ssn6-Tup1-dependent negative regulatory element controls sporulation-specific expression of DIT1 and DIT2 in Saccharomyces cerevisiae. Friesen H, et al. Mol Cell Biol, 1997 Jan. PMID 8972192, Free PMC Article
    4. Studies on the Properties of the Sporulation Specific Protein Dit1 and its Product Formyl Tyrosine. Basiony M, et al. J Fungi (Basel), 2020 Jun 3. PMID 32503197, Free PMC Article
    5. Characterization of a yeast sporulation-specific P450 family protein, Dit2, using an in vitro assay to crosslink formyl tyrosine. Bemena LD, et al. J Biochem, 2018 Feb 1. PMID 29365103

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NADPH dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore wall assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative cytochrome P450
    NP_010690.1
    • N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1272234..1273703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180710.1 → NP_010690.1  TPA: putative cytochrome P450 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010690.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT34, P21595
      UniProtKB/TrEMBL
      G2WBE0, N1P7D5
      Conserved Domains (1) summary
      cd11070
      Location:65 → 485
      CYP56-like; cytochrome P450 family 56-like fungal cytochrome P450s
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21595.2

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