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    Rin2 Ras and Rab interactor 2 [ Mus musculus (house mouse) ]

    Gene ID: 74030, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rin2provided by MGI
    Official Full Name
    Ras and Rab interactor 2provided by MGI
    Primary source
    MGI:MGI:1921280
    See related
    Ensembl:ENSMUSG00000001768 AllianceGenome:MGI:1921280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RASSF4; 2010003K16Rik; 4632403N06Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in positive regulation of endothelial cell migration; positive regulation of endothelial cell-matrix adhesion via fibronectin; and positive regulation of vasculogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and endocytic vesicle. Orthologous to human RIN2 (Ras and Rab interactor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 13.6), limb E14.5 (RPKM 10.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rin2 in Genome Data Viewer
    Location:
    2 G1; 2 71.25 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (145613647..145729536)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (145771727..145887616)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC039771 Neighboring gene predicted gene, 54120 Neighboring gene predicted gene, 34513 Neighboring gene STARR-seq mESC enhancer starr_05929 Neighboring gene predicted gene, 54121 Neighboring gene STARR-seq mESC enhancer starr_05932 Neighboring gene predicted gene, 39954 Neighboring gene STARR-seq mESC enhancer starr_05933 Neighboring gene STARR-positive B cell enhancer ABC_E8796 Neighboring gene TM2 domain containing 1 pseudogene Neighboring gene N(alpha)-acetyltransferase 20, NatB catalytic subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling. Qiao L, et al. Cell Signal, 2023 Dec. PMID 37827343
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling.
      Title: NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras and Rab interactor 2
    Names
    ras interaction/interference protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001406508.1 → NP_001393437.1  ras and Rab interactor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672100
      UniProtKB/Swiss-Prot
      A8Y5L0, Q3U6Z8, Q3UAK3, Q3UC54, Q99K06, Q9D684

    2. NM_001406509.1 → NP_001393438.1  ras and Rab interactor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672100
      UniProtKB/Swiss-Prot
      A8Y5L0, Q3U6Z8, Q3UAK3, Q3UC54, Q99K06, Q9D684
      Related
      ENSMUSP00000105632.2, ENSMUST00000110005.8

    3. NM_001406510.1 → NP_001393439.1  ras and Rab interactor 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL672100

    4. NM_028724.5 → NP_083000.5  ras and Rab interactor 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL672100
      Consensus CDS
      CCDS50734.1
      UniProtKB/TrEMBL
      F8WGD2
      Related
      ENSMUSP00000092053.5, ENSMUST00000094480.11
      Conserved Domains (3) summary
      smart00167
      Location:614 → 730
      VPS9; Domain present in VPS9
      cd10394
      Location:41 → 140
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:751 → 841
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      145613647..145729536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500269.1 → XP_006500332.1  ras and Rab interactor 2 isoform X1

      See identical proteins and their annotated locations for XP_006500332.1

      UniProtKB/Swiss-Prot
      A8Y5L0, Q3U6Z8, Q3UAK3, Q3UC54, Q99K06, Q9D684
      Conserved Domains (3) summary
      smart00167
      Location:659 → 775
      VPS9; Domain present in VPS9
      cd10394
      Location:86 → 185
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:796 → 886
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)

    2. XM_036162625.1 → XP_036018518.1  ras and Rab interactor 2 isoform X2

      Conserved Domains (3) summary
      smart00167
      Location:606 → 722
      VPS9; Domain present in VPS9
      cd10394
      Location:33 → 132
      SH2_RIN2; Src homology 2 (SH2) domain found in Ras and Rab interactor 2 (RIN2)-like proteins
      cd16131
      Location:743 → 833
      RA_Rin2; Ras-associating (RA) domain found in Ras and Rab interactor 2 (Rin2)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D684.3 GenPept UniProtKB/Swiss-Prot:Q9D684

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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