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    Rhoc ras homolog family member C [ Mus musculus (house mouse) ]

    Gene ID: 11853, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rhocprovided by MGI
    Official Full Name
    ras homolog family member Cprovided by MGI
    Primary source
    MGI:MGI:106028
    See related
    Ensembl:ENSMUSG00000002233 AllianceGenome:MGI:106028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arh9; Arhc
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in apical junction assembly and positive regulation of protein-containing complex assembly. Located in nucleus; plasma membrane; and stereocilium. Is expressed in hippocampus. Orthologous to human RHOC (ras homolog family member C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 107.6), colon adult (RPKM 105.0) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Rhoc in Genome Data Viewer
    Location:
    3 F2.2; 3 45.86 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104696350..104701775)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104789034..104794459)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 3 Neighboring gene STARR-seq mESC enhancer starr_08620 Neighboring gene protein phosphatase 1J Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene STARR-seq mESC enhancer starr_08622 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables protein binding PubMed 
    enables protein kinase binding  
    Process Evidence Code Pubs
    involved_in actin filament organization  
    involved_in apical junction assembly PubMed 
    involved_in apical junction assembly  
    involved_in cell migration  
    involved_in mitotic cytokinesis  
    involved_in mitotic cytokinesis  
    involved_in mitotic cytokinesis  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of lipase activity  
    involved_in positive regulation of protein-containing complex assembly PubMed 
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of stress fiber assembly  
    involved_in regulation of actin cytoskeleton organization  
    involved_in signal transduction  
    involved_in skeletal muscle satellite cell migration  
    involved_in small GTPase-mediated signal transduction  
    involved_in wound healing, spreading of cells  
    Component Evidence Code Pubs
    located_in cleavage furrow  
    located_in cleavage furrow  
    is_active_in cytosol  
    located_in cytosol  
    located_in membrane  
    located_in nucleus PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in stereocilium PubMed 

    General protein information

    Preferred Names
    rho-related GTP-binding protein RhoC
    Names
    SIG-61
    aplysia ras-related homolog 9 (RhoC)
    ras homolog 9 (RhoC)
    ras homolog gene family, member C
    silica-induced gene 61 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291859.1NP_001278788.1  rho-related GTP-binding protein RhoC

      See identical proteins and their annotated locations for NP_001278788.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BY315470, CO044736, CX223083
      Consensus CDS
      CCDS17704.1
      UniProtKB/Swiss-Prot
      Q3TUN0, Q62159
      UniProtKB/TrEMBL
      Q3TN61
      Related
      ENSMUSP00000102399.2, ENSMUST00000106787.8
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
    2. NM_007484.2NP_031510.2  rho-related GTP-binding protein RhoC

      See identical proteins and their annotated locations for NP_031510.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI324259, AK160650, BY147599
      Consensus CDS
      CCDS17704.1
      UniProtKB/Swiss-Prot
      Q3TUN0, Q62159
      UniProtKB/TrEMBL
      Q3TN61
      Related
      ENSMUSP00000002303.6, ENSMUST00000002303.12
      Conserved Domains (1) summary
      cd01870
      Location:5179
      RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      104696350..104701775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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