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    Tmt1b thiol methyltransferase 1B [ Mus musculus (house mouse) ]

    Gene ID: 71664, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmt1bprovided by MGI
    Official Full Name
    thiol methyltransferase 1Bprovided by MGI
    Primary source
    MGI:MGI:1918914
    See related
    Ensembl:ENSMUSG00000025347 AllianceGenome:MGI:1918914
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mettl7b; 0610006F02Rik
    Summary
    Predicted to enable thiol S-methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in cytosol; endoplasmic reticulum membrane; and lipid droplet. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver; and spleen. Orthologous to human TMT1B (thiol methyltransferase 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 329.6), kidney adult (RPKM 92.7) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmt1b in Genome Data Viewer
    Location:
    10 D3; 10 77.2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128794146..128796857, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128958277..128960988, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 5 Neighboring gene STARR-positive B cell enhancer ABC_E6941 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1 Neighboring gene integrin alpha 7 Neighboring gene predicted gene, 25494 Neighboring gene RIKEN cDNA 9030616G12 gene Neighboring gene olfactory receptor family 10 subfamily P member 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells. Franjic D, et al. Neuron, 2022 Feb 2. PMID 34798047, Free PMC Article
    2. Methyltransferase like 7B is upregulated in sepsis and modulates lipopolysaccharide-induced inflammatory response and macrophage polarization. Huang D, et al. Bioengineered, 2022 May. PMID 35603523, Free PMC Article
    3. A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea. Kathiresan T, et al. Mol Cell Proteomics, 2009 Aug. PMID 19423573, Free PMC Article
    4. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Methyltransferase like 7B is upregulated in sepsis and modulates lipopolysaccharide-induced inflammatory response and macrophage polarization.
      Title: Methyltransferase like 7B is upregulated in sepsis and modulates lipopolysaccharide-induced inflammatory response and macrophage polarization.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables thiol S-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiol S-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thiol S-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thiol S-methyltransferase TMT1B
    Names
    methyltransferase like 7B
    methyltransferase-like protein 7B
    thiol S-methyltransferase METTL7B
    NP_082129.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027853.2 → NP_082129.2  thiol S-methyltransferase TMT1B precursor

      See identical proteins and their annotated locations for NP_082129.2

      Status: VALIDATED

      Source sequence(s)
      AK002239
      Consensus CDS
      CCDS24301.1
      UniProtKB/Swiss-Prot
      Q78ID2, Q9DD20
      Related
      ENSMUSP00000026398.4, ENSMUST00000026398.5
      Conserved Domains (2) summary
      COG0500
      Location:33 → 192
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08241
      Location:75 → 172
      Methyltransf_11; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128794146..128796857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DD20.2 GenPept UniProtKB/Swiss-Prot:Q9DD20

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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