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    Zswim2 zinc finger SWIM-type containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 71861, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zswim2provided by MGI
    Official Full Name
    zinc finger SWIM-type containing 2provided by MGI
    Primary source
    MGI:MGI:1919111
    See related
    Ensembl:ENSMUSG00000034552 AllianceGenome:MGI:1919111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MEX; 1700025P14Rik; 4933437F18Rik
    Summary
    Enables ubiquitin protein ligase activity. Involved in protein polyubiquitination. Acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Orthologous to human ZSWIM2 (zinc finger SWIM-type containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 15.6) See more
    Orthologs
    human all
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    Genomic context

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    See Zswim2 in Genome Data Viewer
    Location:
    2 D; 2 49.33 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (83745414..83771596, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (83915079..83941226, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene integrin alpha V Neighboring gene DNA methyltransferase 3-like, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2039 Neighboring gene STARR-positive B cell enhancer ABC_E7832 Neighboring gene family with sequence similarity 171, member B Neighboring gene STARR-positive B cell enhancer ABC_E11143 Neighboring gene CWC22 spliceosome-associated protein, retrotransposed 1 Neighboring gene CWC22 spliceosome-associated protein, retrotransposed 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice. Nozawa K, et al. BMC Biol, 2022 Jul 13. PMID 35831855, Free PMC Article
    2. MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Nishito Y, et al. Biochem J, 2006 Jun 15. PMID 16522193, Free PMC Article
    3. An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance. Li N, et al. Oncogenesis, 2019 Feb 19. PMID 30783098, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase Zswim2
    Names
    MEKK1-related protein X
    RING-type E3 ubiquitin transferase Zswim2
    ZZ-type zinc finger-containing protein 2
    zinc finger SWIM domain-containing protein 2
    zinc finger, SWIM domain containing 2
    NP_001405665.1
    NP_082240.1
    XP_036018470.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418736.1 → NP_001405665.1  E3 ubiquitin-protein ligase Zswim2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772256

    2. NM_027964.3 → NP_082240.1  E3 ubiquitin-protein ligase Zswim2 isoform 1

      See identical proteins and their annotated locations for NP_082240.1

      Status: VALIDATED

      Source sequence(s)
      AL772256
      Consensus CDS
      CCDS16183.1
      UniProtKB/Swiss-Prot
      Q9D9X6
      UniProtKB/TrEMBL
      Q0VB10
      Related
      ENSMUSP00000044913.2, ENSMUST00000038223.8
      Conserved Domains (3) summary
      pfam04434
      Location:54 → 86
      SWIM; SWIM zinc finger
      pfam13639
      Location:343 → 386
      zf-RING_2; Ring finger domain
      cl00295
      Location:233 → 271
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      83745414..83771596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162577.1 → XP_036018470.1  E3 ubiquitin-protein ligase Zswim2 isoform X1

      UniProtKB/TrEMBL
      B2FDH1
      Related
      ENSMUSP00000119439.2, ENSMUST00000152829.2
      Conserved Domains (4) summary
      pfam04434
      Location:54 → 86
      SWIM; SWIM zinc finger
      cd16494
      Location:144 → 202
      RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
      cl00295
      Location:233 → 271
      ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
      cl17238
      Location:343 → 365
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9X6.1 GenPept UniProtKB/Swiss-Prot:Q9D9X6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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