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    PDB1 pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852522, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PDB1
    Official Full Name
    pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta
    Primary source
    SGD:S000000425
    Locus tag
    YBR221C
    See related
    AllianceGenome:SGD:S000000425; FungiDB:YBR221C; VEuPathDB:YBR221C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrial nucleoid. Part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHB (pyruvate dehydrogenase E1 subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PDB1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (665153..666253, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene pyruvate carboxylase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Pcs60p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of PDH beta 1, the structural gene for the pyruvate dehydrogenase beta subunit from Saccharomyces cerevisiae. Miran SG, et al. Proc Natl Acad Sci U S A, 1993 Feb 15. PMID 8433986, Free PMC Article
    2. QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism. Eder M, et al. Sci Rep, 2020 Feb 7. PMID 32034164, Free PMC Article
    3. Genetic analysis of the Warburg effect in yeast. Olayanju B, et al. Adv Biol Regul, 2015 Jan. PMID 25446884, Free PMC Article
    4. Disruption and mutagenesis of the Saccharomyces cerevisiae PDX1 gene encoding the protein X component of the pyruvate dehydrogenase complex. Lawson JE, et al. Biochemistry, 1991 Mar 19. PMID 2007123
    5. Expression, purification, and characterization of the dihydrolipoamide dehydrogenase-binding protein of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae. Maeng CY, et al. Biochemistry, 1994 Nov 22. PMID 7947791

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism.
      Title: QTL mapping of modelled metabolic fluxes reveals gene variants impacting yeast central carbon metabolism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acetyl-CoA biosynthetic process from pyruvate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of pyruvate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pyruvate dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta
    NP_009780.1
    • E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      665153..666253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178569.1 → NP_009780.1  TPA: pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009780.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQL7, P32473
      UniProtKB/TrEMBL
      A6ZLG0, B3LMU1, B5VEH3, C7GMT2, D3UEW6, G2W9M4, N1P8H2
      Conserved Domains (1) summary
      PRK11892
      Location:6 → 362
      PRK11892; pyruvate dehydrogenase subunit beta; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32473.2

    Gene LinkOut

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