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    Asb1 ankyrin repeat and SOCS box-containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 65247, updated on 9-Dec-2024

    Summary

    Official Symbol
    Asb1provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 1provided by MGI
    Primary source
    MGI:MGI:1929735
    See related
    Ensembl:ENSMUSG00000026311 AllianceGenome:MGI:1929735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1146; 1700029O08Rik; 1700054C17Rik
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within male genitalia development. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB1 (ankyrin repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 17.6), liver E14 (RPKM 5.4) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Asb1 in Genome Data Viewer
    Location:
    1 D; 1 46.19 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91467725..91487312)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91540001..91559590)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nucleolar complex associated 3 homolog pseudogene Neighboring gene TRAF3 interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_01698 Neighboring gene STARR-positive B cell enhancer ABC_E1555 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93497438-93497621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93498155-93498356 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93527619-93527999 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93529086-93529287 Neighboring gene predicted gene 28380 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93547237-93547420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93555659-93555944 Neighboring gene STARR-seq mESC enhancer starr_01699 Neighboring gene STARR-seq mESC enhancer starr_01700 Neighboring gene twist basic helix-loop-helix transcription factor 2 Neighboring gene predicted gene, 46117

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of ubiquitin ligase complex  
    part_of ubiquitin ligase complex  
    part_of ubiquitin ligase complex  

    General protein information

    Preferred Names
    ankyrin repeat and SOCS box protein 1
    Names
    ASB-1
    ankyrin repeat and SOCS box-containing protein 1
    ankyrin repeat-containing SOCS box protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039126.2NP_001034215.1  ankyrin repeat and SOCS box protein 1 isoform a

      See identical proteins and their annotated locations for NP_001034215.1

      Status: VALIDATED

      Source sequence(s)
      AC109199, AK153774, BY231875
      Consensus CDS
      CCDS35665.1
      UniProtKB/Swiss-Prot
      Q9WV74
      UniProtKB/TrEMBL
      Q3U5A0, Q80TI9
      Related
      ENSMUSP00000084054.6, ENSMUST00000086843.11
      Conserved Domains (5) summary
      cd00204
      Location:80213
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03720
      Location:295336
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      pfam12796
      Location:83174
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:4099
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:80109
      ANK; ANK repeat [structural motif]
    2. NM_023046.4NP_075533.3  ankyrin repeat and SOCS box protein 1 isoform b

      See identical proteins and their annotated locations for NP_075533.3

      Status: VALIDATED

      Source sequence(s)
      AC109199, AK153774, BU938650
      Consensus CDS
      CCDS35666.1
      UniProtKB/TrEMBL
      G3X9J5, Q9D9S9
      Related
      ENSMUSP00000140731.2, ENSMUST00000188879.2
      Conserved Domains (5) summary
      cd00204
      Location:72205
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03720
      Location:287328
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      pfam12796
      Location:75166
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:3291
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:72101
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      91467725..91487312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529790.5XP_006529853.1  ankyrin repeat and SOCS box protein 1 isoform X2

      UniProtKB/TrEMBL
      S4W6L8
      Related
      ENSMUSP00000140281.2, ENSMUST00000190484.7
      Conserved Domains (3) summary
      COG0666
      Location:21164
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd03720
      Location:194235
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      sd00045
      Location:3972
      ANK; ANK repeat [structural motif]
    2. XM_006529789.3XP_006529852.1  ankyrin repeat and SOCS box protein 1 isoform X1

      UniProtKB/TrEMBL
      Q9D9S9
      Conserved Domains (5) summary
      PHA02875
      Location:77263
      PHA02875; ankyrin repeat protein; Provisional
      cd03720
      Location:291332
      SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      sd00045
      Location:76105
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:79170
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:19105
      Ank_2; Ankyrin repeats (3 copies)
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