U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DPB4 DNA polymerase epsilon noncatalytic subunit [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851699, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    DPB4
    Official Full Name
    DNA polymerase epsilon noncatalytic subunit
    Primary source
    SGD:S000002528
    Locus tag
    YDR121W
    See related
    AllianceGenome:SGD:S000002528; FungiDB:YDR121W; VEuPathDB:YDR121W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables nucleosomal DNA binding activity. Contributes to DNA binding activity; DNA polymerase processivity factor activity; and single-stranded DNA 3'-5' DNA exonuclease activity. Involved in DNA metabolic process; chromatin remodeling; and regulation of DNA double-strand break processing. Part of CHRAC and epsilon DNA polymerase complex. Orthologous to human POLE3 (DNA polymerase epsilon 3, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See DPB4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (693585..694175)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cox26p Neighboring gene tRNA (guanine26-N2)-dimethyltransferase Neighboring gene serine/threonine protein kinase KIN1 Neighboring gene Ino2p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Conformational changes associated with template commitment in ATP-dependent chromatin remodeling by ISW2. Gangaraju VK, et al. Mol Cell, 2009 Jul 10. PMID 19595716, Free PMC Article
    2. The Dpb4 subunit of ISW2 is anchored to extranucleosomal DNA. Dang W, et al. J Biol Chem, 2007 Jul 6. PMID 17491017
    3. Synthesis of DNA by DNA polymerase epsilon in vitro. Lee SH, et al. J Biol Chem, 1991 Nov 25. PMID 1682323
    4. Translesion synthesis of abasic sites by yeast DNA polymerase epsilon. Sabouri N, et al. J Biol Chem, 2009 Nov 13. PMID 19776424, Free PMC Article
    5. Double-stranded DNA binding, an unusual property of DNA polymerase epsilon, promotes epigenetic silencing in Saccharomyces cerevisiae. Tsubota T, et al. J Biol Chem, 2006 Oct 27. PMID 16916794

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to DNA polymerase processivity factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA polymerase processivity factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleosomal DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to single-stranded DNA 3'-5' DNA exonuclease activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in error-prone translesion synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leading strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leading strand elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in leading strand elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA double-strand break processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CHRAC IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CHRAC IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CHRAC IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of epsilon DNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of epsilon DNA polymerase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA polymerase epsilon noncatalytic subunit
    NP_010406.3
    • Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      693585..694175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180429.3 → NP_010406.3  TPA: DNA polymerase epsilon noncatalytic subunit [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010406.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSA7, Q04603
      UniProtKB/TrEMBL
      B3LGF5, B5VG16, C7GIM9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04603.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous