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    FLC2 flavin adenine dinucleotide transporter FLC2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851246, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FLC2
    Official Full Name
    flavin adenine dinucleotide transporter FLC2
    Primary source
    SGD:S000000049
    Locus tag
    YAL053W
    See related
    AllianceGenome:SGD:S000000049; FungiDB:YAL053W; VEuPathDB:YAL053W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables FAD transmembrane transporter activity. Involved in several processes, including FAD transport; cellular hypotonic response; and protein folding. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FLC2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (45899..48250)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene ubiquitin-protein transferase activating protein PEX22 Neighboring gene acetate--CoA ligase 1 Neighboring gene oleate-activated transcription factor OAF1 Neighboring gene protein AIM2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A microbial TRP-like polycystic-kidney-disease-related ion channel gene. Palmer CP, et al. Biochem J, 2005 Apr 1. PMID 15537393, Free PMC Article
    2. A combined system for engineering glycosylation efficiency and glycan structure in Saccharomyces cerevisiae. Parsaie Nasab F, et al. Appl Environ Microbiol, 2013 Feb. PMID 23204425, Free PMC Article
    3. Hypotonic stress-induced calcium signaling in Saccharomyces cerevisiae involves TRP-like transporters on the endoplasmic reticulum membrane. Rigamonti M, et al. Cell Calcium, 2015 Feb. PMID 25573187
    4. A screen for genes of heme uptake identifies the FLC family required for import of FAD into the endoplasmic reticulum. Protchenko O, et al. J Biol Chem, 2006 Jul 28. PMID 16717099
    5. Chemogenetic E-MAP in Saccharomyces cerevisiae for Identification of Membrane Transporters Operating Lipid Flip Flop. Vazquez HM, et al. PLoS Genet, 2016 Jul. PMID 27462707, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FAD transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in FAD transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in FAD transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular hypotonic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    flavin adenine dinucleotide transporter FLC2
    NP_009348.2
    • Putative calcium channel involved in calcium release under hypotonic stress; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; targeted to vacuole via AP-3 pathway; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      45899..48250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178196.2 → NP_009348.2  TPA: flavin adenine dinucleotide transporter FLC2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009348.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPG5, P39719, Q05165
      UniProtKB/TrEMBL
      A7A0B5, B3LUY7, C7GPI6, G2W8H9, N1PAZ8
      Conserved Domains (2) summary
      pfam06011
      Location:182 → 628
      TRP; Transient receptor potential (TRP) ion channel
      pfam14558
      Location:38 → 177
      TRP_N; ML-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39719.2

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