Meaf6 MYST/Esa1-associated factor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Meaf6provided by MGI
Official Full Name: MYST/Esa1-associated factor 6provided by MGI
Primary source: MGI:MGI:1917338
See related: Ensembl:ENSMUSG00000028863 AllianceGenome:MGI:1917338
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310005N01Rik; 2810036M01Rik
Summary: Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in regulation of cell cycle; regulation of cell growth; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in kinetochore; nucleolus; and nucleoplasm. Predicted to be part of MOZ/MORF histone acetyltransferase complex; NuA4 histone acetyltransferase complex; and nucleosome. Orthologous to human MEAF6 (MYST/Esa1 associated factor 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 18.5), whole brain E14.5 (RPKM 16.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 58.03 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (124978883..125007031)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (125085113..125113238)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.
Title: MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to histone H3K14 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H3K14 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to histone H4K12 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K12 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to histone H4K5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K5 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to histone H4K8 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K8 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of developmental process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of hemopoiesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of MOZ/MORF histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of MOZ/MORF histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of NuA4 histone acetyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: chromatin modification-related protein MEAF6

Names: esa1-associated factor 6 homolog; protein EAF6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290701.2 → NP_001277630.1 chromatin modification-related protein MEAF6 isoform 2

See identical proteins and their annotated locations for NP_001277630.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in 3' coding region and uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK009177, AK012867, AL626775, AW123768, BY133395, BY600332

Consensus CDS

CCDS71467.1

UniProtKB/Swiss-Prot

B1ASC6, Q2VPQ9, Q9D7J5

UniProtKB/TrEMBL

V9GX42

Related

ENSMUSP00000122288.2, ENSMUST00000154689.8

Conserved Domains (1) summary

pfam09340
Location:18 → 96

NuA4; Histone acetyltransferase subunit NuA4
NM_001374123.1 → NP_001361052.1 chromatin modification-related protein MEAF6 isoform 3

Status: VALIDATED

Source sequence(s)

AK012867, AL626775, BQ178199, CO428776

UniProtKB/TrEMBL

B1ASC8

Related

ENSMUSP00000101777.4, ENSMUST00000106171.9

Conserved Domains (1) summary

pfam09340
Location:18 → 96

NuA4; Histone acetyltransferase subunit NuA4
NM_027310.5 → NP_081586.1 chromatin modification-related protein MEAF6 isoform 1

See identical proteins and their annotated locations for NP_081586.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK009177, AK012867, AL626775, AW123768, BY133395, BY600332

Consensus CDS

CCDS18637.1

UniProtKB/TrEMBL

V9GX42

Related

ENSMUSP00000053543.5, ENSMUST00000055213.11

Conserved Domains (1) summary

pfam09340
Location:18 → 96

NuA4; Histone acetyltransferase subunit NuA4