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    VAN1 Van1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VAN1
    Official Full Name
    Van1p
    Primary source
    SGD:S000004583
    Locus tag
    YML115C
    See related
    AllianceGenome:SGD:S000004583; FungiDB:YML115C; VEuPathDB:YML115C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LDB13; VRG7; VRG8
    Summary
    Contributes to alpha-1,6-mannosyltransferase activity. Involved in cell wall mannoprotein biosynthetic process and protein N-linked glycosylation. Part of mannan polymerase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VAN1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (40187..41794, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Nab6p Neighboring gene borate transporter Neighboring gene Taf8p Neighboring gene Dat1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization of the FAR3 gene: genetic mapping and molecular cloning using a chromosome walk-'n'-roll strategy. Horecka J. Yeast, 1995 Jun 15. PMID 7483842
    2. Sodium orthovanadate-resistant mutants of Saccharomyces cerevisiae show defects in Golgi-mediated protein glycosylation, sporulation and detergent resistance. Kanik-Ennulat C, et al. Genetics, 1995 Jul. PMID 7672592, Free PMC Article
    3. Vanadate-resistant mutants of Saccharomyces cerevisiae show alterations in protein phosphorylation and growth control. Kanik-Ennulat C, et al. Mol Cell Biol, 1990 Mar. PMID 2137555, Free PMC Article
    4. Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis. Striebeck A, et al. Open Biol, 2013 Sep 11. PMID 24026536, Free PMC Article
    5. The components of the Saccharomyces cerevisiae mannosyltransferase complex M-Pol I have distinct functions in mannan synthesis. Stolz J, et al. J Biol Chem, 2002 Nov 22. PMID 12235155

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results provide further information on the role of M-Pol I and its subunits Mnn9 and Van1 in mannan biosynthesis.
      Title: Expression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to alpha-1,6-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to alpha-1,6-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall mannoprotein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell wall mannoprotein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mannan polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mannan polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Van1p
    NP_013592.1
    • Component of the mannan polymerase I; complex contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      40187..41794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182477.1 → NP_013592.1  TPA: Van1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013592.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0G9, P23642
      UniProtKB/TrEMBL
      A6ZLU9, B3LLE4, C7GV97, C8ZE88, G2WJU1, N1NY78
      Conserved Domains (1) summary
      pfam03452
      Location:171 → 480
      Anp1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23642.3

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