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    MAM3 Mam3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854094, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MAM3
    Official Full Name
    Mam3p
    Primary source
    SGD:S000005421
    Locus tag
    YOL060C
    See related
    AllianceGenome:SGD:S000005421; FungiDB:YOL060C; VEuPathDB:YOL060C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable transmembrane transporter activity. Involved in intracellular manganese ion homeostasis and mitochondrion organization. Acts upstream of or within intracellular magnesium ion homeostasis. Located in endoplasmic reticulum and fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in Jalili syndrome and renal hypomagnesemia 6. Orthologous to several human genes including CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1); CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2); and CNNM3 (cyclin and CBS domain divalent metal cation transport mediator 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MAM3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (214017..216137, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Apm4p Neighboring gene ribose phosphate diphosphokinase subunit PRS5 Neighboring gene glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Neighboring gene argininosuccinate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenotypic switching in Candida glabrata involves phase-specific regulation of the metallothionein gene MT-II and the newly discovered hemolysin gene HLP. Lachke SA, et al. Infect Immun, 2000 Feb. PMID 10639459, Free PMC Article
    2. Conserved mechanism for vacuolar magnesium sequestration in yeast and plant cells. Tang RJ, et al. Nat Plants, 2022 Feb. PMID 35087208
    3. A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology. Ricarte F, et al. PLoS One, 2011. PMID 21912603, Free PMC Article
    4. Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Entian KD, et al. Mol Gen Genet, 1999 Dec. PMID 10628851
    5. Get1p and Get2p are required for maintenance of mitochondrial morphology and normal cardiolipin levels. Joshi AS, et al. FEMS Yeast Res, 2016 May. PMID 26926495, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. first report of a eukaryotic ACDP family protein, MAM3, involved in metal homoeostasis
      Title: Manganese toxicity and Saccharomyces cerevisiae Mam3p, a member of the ACDP (ancient conserved domain protein) family.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular magnesium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular manganese ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in magnesium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mam3p
    NP_014581.1
    • Protein involved in magnesium homeostasis; required for Mg2+ sequestration in vacuole; required for normal mitochondrial morphology; has similarity to hemolysins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      214017..216137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183315.1 → NP_014581.1  TPA: Mam3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014581.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W207, Q12296
      UniProtKB/TrEMBL
      A6ZNF0, N1NX85
      Conserved Domains (1) summary
      COG1253
      Location:35 → 396
      TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12296.1

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