GYP5 GTPase-activating protein GYP5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GYP5
Official Full Name: GTPase-activating protein GYP5
Primary source: SGD:S000006170
Locus tag: YPL249C
See related: AllianceGenome:SGD:S000006170; FungiDB:YPL249C; VEuPathDB:YPL249C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables GTPase activator activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in several cellular components, including cellular bud tip; incipient cellular bud site; and mating projection tip. Orthologous to several human genes including RABGAP1 (RAB GTPase activating protein 1); RABGAP1L (RAB GTPase activating protein 1 like); and EVI5 (ecotropic viral integration site 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GYP5 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (76669..79353, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In gyp5Deltagyl1Delta cells, Rvs167p is not correctly localized to the small-bud tip.
Title: The RabGAP proteins Gyp5p and Gyl1p recruit the BAR domain protein Rvs167p for polarized exocytosis.
Results describe the interaction between Gyp5p and Gyl1p as well as the mechanism of their localization to the sites of polarized growth, and show that purified recombinant Gyp5p and Gyl1p interact directly in vitro.
Title: Interdependence of the Ypt/RabGAP Gyp5p and Gyl1p for recruitment to the sites of polarized growth.
These data suggest that Gyp5p and Gyl1p are involved in control of polarized exocytosis.
Title: Gyp5p and Gyl1p are involved in the control of polarized exocytosis in budding yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi-associated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck	HDA more info	PubMed
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
located_in cellular bud tip	HDA more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in site of polarized growth	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GTPase-activating protein GYP5

NP_015075.1

GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

76669..79353 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184063.1 → NP_015075.1 TPA: GTPase-activating protein GYP5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015075.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3C2, Q12344

UniProtKB/TrEMBL

B3LKI3, N1NVZ8

Conserved Domains (2) summary

COG5210
Location:154 → 737

COG5210; GTPase-activating protein [General function prediction only]

TIGR02168
Location:726 → 891

SMC_prok_B; chromosome segregation protein SMC, common bacterial type