IFH1 Ifh1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: IFH1
Official Full Name: Ifh1p
Primary source: SGD:S000004213
Locus tag: YLR223C
See related: AllianceGenome:SGD:S000004213; FungiDB:YLR223C; VEuPathDB:YLR223C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables transcription coactivator activity. Involved in positive regulation of ribosomal protein gene transcription by RNA polymerase II and subtelomeric heterochromatin formation. Located in chromatin and nucleolus. Part of CURI complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See IFH1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (582233..585490, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1.
Title: Increased RNA production in Saccharomyces cerevisiae by simultaneously overexpressing FHL1, IFH1, and SSF2 and deleting HRP1.
The role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae has been described.
Title: Role of CK2-dependent phosphorylation of Ifh1 and Crf1 in transcriptional regulation of ribosomal protein genes in Saccharomyces cerevisiae.
A dynamic Ifh1-Utp22 interaction fine-tunes ribosomal protein gene (RPG) expression to coordinate RPG and rRNA transcription.
Title: A Molecular Titration System Coordinates Ribosomal Protein Gene Transcription with Ribosomal RNA Synthesis.
data suggest a novel mechanism of regulation whereby Gcn5 functions to titrate the activity of Ifh1 following its recruitment to RP promoters to provide more than an all-or-nothing mode of transcriptional regulation
Title: Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1.
activation domain (AD) of the ribosomal protein genes activator Ifh1p was identified.
Title: Identification and characterization of the activation domain of Ifh1, an activator of model TATA-less genes.
Fhl1p and Ifh1p are key players in the transcription of ribosomal protein genes
Title: Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins.
central role for Ifh1 and Fhl1 in ribosomal protein gene regulation
Title: Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1.
Ifh1 association with promoters is the key regulatory step for coordinate expression of ribosomal protein genes
Title: The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes.
the interaction between Fhl1p and Ifh1p is critical for the regulation of CPC2 transcription during utilization of different carbon sources.
Title: The yeast CPC2/ASC1 gene is regulated by the transcription factors Fhl1p and Ifh1p.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables transcription coactivator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ribosomal protein gene transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in subtelomeric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CURI complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ifh1p

NP_013324.1

Coactivator, regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing; regulated by acetylation and phosphorylation at different growth states via TORC1 signaling; IFH1 has a paralog, CRF1, that arose from the whole genome duplication