CIT3 citrate (Si)-synthase CIT3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CIT3
Official Full Name: citrate (Si)-synthase CIT3
Primary source: SGD:S000006205
Locus tag: YPR001W
See related: AllianceGenome:SGD:S000006205; FungiDB:YPR001W; VEuPathDB:YPR001W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 2-methylcitrate synthase activity and citrate (Si)-synthase activity. Involved in propionate catabolic process, 2-methylcitrate cycle and tricarboxylic acid cycle. Located in mitochondrion. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CIT3 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (556377..557837)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 2-methylcitrate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-methylcitrate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2-methylcitrate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acyltransferase activity, acyl groups converted into alkyl on transfer	IEA Inferred from Electronic Annotation more info
enables citrate (Si)-synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables citrate (Si)-synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables citrate (Si)-synthase activity	IEA Inferred from Electronic Annotation more info
enables citrate (Si)-synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables citrate synthase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in propionate catabolic process, 2-methylcitrate cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: citrate (Si)-synthase CIT3

NP_015325.1

EC 2.3.3.1

Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

556377..557837

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184098.1 → NP_015325.1 TPA: citrate (Si)-synthase CIT3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015325.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W412, P43635

UniProtKB/TrEMBL

B3LL62, B5VTG1, C7GV45, C8ZJ26, N1P1X2

Conserved Domains (1) summary

cd06106
Location:29 → 474

ScCit3_like; Saccharomyces cerevisiae (Sc) 2-methylcitrate synthase Cit3-like. 2-methylcitrate synthase (2MCS) catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxaloacetate (OAA) to form 2-methylcitrate and CoA. Citrate synthase (CS) catalyzes the ...