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    NRG2 Nrg2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852358, updated on 27-Dec-2024

    Summary

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    Official Symbol
    NRG2
    Official Full Name
    Nrg2p
    Primary source
    SGD:S000000270
    Locus tag
    YBR066C
    See related
    AllianceGenome:SGD:S000000270; FungiDB:YBR066C; VEuPathDB:YBR066C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sequence-specific DNA binding activity. Involved in cell adhesion involved in single-species biofilm formation; negative regulation of growth of unicellular organism as a thread of attached cells; and negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NRG2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (370037..370699, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Cnm1p Neighboring gene Ecm2p Neighboring gene putative lipase Neighboring gene branched-chain amino acid permease BAP2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nrg1 and nrg2 transcriptional repressors are differently regulated in response to carbon source. Berkey CD, et al. Eukaryot Cell, 2004 Apr. PMID 15075261, Free PMC Article
    2. Interaction of the repressors Nrg1 and Nrg2 with the Snf1 protein kinase in Saccharomyces cerevisiae. Vyas VK, et al. Genetics, 2001 Jun. PMID 11404322, Free PMC Article
    3. Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation. Kuchin S, et al. Mol Cell Biol, 2002 Jun. PMID 12024013, Free PMC Article
    4. Role of the yeast Snf1 protein kinase in invasive growth. Kuchin S, et al. Biochem Soc Trans, 2003 Feb. PMID 12546679
    5. De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis. Fordyce PM, et al. Nat Biotechnol, 2010 Sep. PMID 20802496, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that Nrg1/Nrg2 fine-tune the regulation of a set of stress-responsive genes.
      Title: Repressors Nrg1 and Nrg2 regulate a set of stress-responsive genes in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion involved in single-species biofilm formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cellular hyperosmotic salinity response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of invasive growth in response to glucose limitation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of pseudohyphal growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Nrg2p
    NP_009622.1
    • Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; activated in stochastic pulses of nuclear localization in response to low glucose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      370037..370699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178414.1 → NP_009622.1  TPA: Nrg2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ65, P38082
      UniProtKB/TrEMBL
      A6ZL10, B3LN83, B5VE31, D3UEG3, G2W971, N1P8B4
      Conserved Domains (2) summary
      COG5048
      Location:72 → 220
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:155 → 175
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38082.1

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