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    RPS18A ribosomal 40S subunit protein S18A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852061, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPS18A
    Official Full Name
    ribosomal 40S subunit protein S18A
    Primary source
    SGD:S000002858
    Locus tag
    YDR450W
    See related
    AllianceGenome:SGD:S000002858; FungiDB:YDR450W; VEuPathDB:YDR450W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable rRNA binding activity. Predicted to be a structural constituent of ribosome. Involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal subunit export from nucleus. Located in mitochondrion. Orthologous to human RPS18 (ribosomal protein S18). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPS18A in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_001136.10 (1359923..1360798)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene chromatin-binding transcription regulator ADA2 Neighboring gene snoRNA-binding rRNA-processing protein UTP6 Neighboring gene Yhp1p Neighboring gene endopolyphosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling. Kasari V, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31299085, Free PMC Article
    2. Ribosomal proteins Rps0 and Rps21 of Saccharomyces cerevisiae have overlapping functions in the maturation of the 3' end of 18S rRNA. Tabb-Massey A, et al. Nucleic Acids Res, 2003 Dec 1. PMID 14627813, Free PMC Article
    3. Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span. Chiocchetti A, et al. Exp Gerontol, 2007 Apr. PMID 17174052
    4. Functional specificity among ribosomal proteins regulates gene expression. Komili S, et al. Cell, 2007 Nov 2. PMID 17981122, Free PMC Article
    5. Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation. Gali VK, et al. PLoS Genet, 2018 Nov. PMID 30418970, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 40S subunit protein S18A
    NP_010738.1
    • Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1359923..1360798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180758.1 → NP_010738.1  TPA: ribosomal 40S subunit protein S18A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010738.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT75, P0CX55, P0CX56, P35271
      UniProtKB/TrEMBL
      A6ZM36, B3LLM6, C7GKP2, C7GT56, C8Z608, G2WK26, N1NZE5
      Conserved Domains (1) summary
      PTZ00134
      Location:1 → 144
      PTZ00134; 40S ribosomal protein S18; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CX55.1
    P0CX56.1

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