ECM14 putative metallocarboxypeptidase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: ECM14
Official Full Name: putative metallocarboxypeptidase
Primary source: SGD:S000001174
Locus tag: YHR132C
See related: AllianceGenome:SGD:S000001174; FungiDB:YHR132C; VEuPathDB:YHR132C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in proteolysis. Is active in fungal-type vacuole. Human ortholog(s) of this gene implicated in chronic kidney disease; familial febrile seizures 11; and familial temporal lobe epilepsy 5. Orthologous to several human genes including CPA1 (carboxypeptidase A1); CPA3 (carboxypeptidase A3); and CPA4 (carboxypeptidase A4). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
NOT enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
NOT involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in fungal-type vacuole	HDA more info	PubMed
located_in vacuole	IEA Inferred from Electronic Annotation more info

NP_012000.1

Putative pseudopeptidase; conserved fungal protein and member of the M14 family of metallocarboxypeptidases but contains substitutions in active site residues important for catalysis and lacks activity with standard substrates; contains a cleavable pro domain; required for normal cell wall assembly in some strains

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The following sections contain reference sequences that belong to a specific genome build. Explain