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    TEN1 Ten1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TEN1
    Official Full Name
    Ten1p
    Primary source
    SGD:S000004000
    Locus tag
    YLR010C
    See related
    AllianceGenome:SGD:S000004000; FungiDB:YLR010C; VEuPathDB:YLR010C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables single-stranded telomeric DNA binding activity; transcription elongation factor activity; and translation elongation factor binding activity. Involved in regulation of nucleobase-containing compound metabolic process and telomere maintenance. Part of CST complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TEN1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (167320..167802, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Pam18p Neighboring gene ATPase-activating ribosome biosynthesis protein Neighboring gene tRNA-Ser Neighboring gene flavin-dependent quinone reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of Stn1p, a single-stranded telomeric DNA binding protein. Qian W, et al. Protein Expr Purif, 2010 Oct. PMID 20576529
    2. RPA-like proteins mediate yeast telomere function. Gao H, et al. Nat Struct Mol Biol, 2007 Mar. PMID 17293872
    3. Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. Grandin N, et al. EMBO J, 2001 Mar 1. PMID 11230140, Free PMC Article
    4. Structure prediction-driven genetics in Saccharomyces cerevisiae identifies an interface between the t-RPA proteins Stn1 and Ten1. Paschini M, et al. Genetics, 2010 May. PMID 20157006, Free PMC Article
    5. Structure of the human telomeric Stn1-Ten1 capping complex. Bryan C, et al. PLoS One, 2013. PMID 23826127, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast.
      Title: Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast.
    2. Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions.
      Title: Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions.
    3. Ten1, Cdc13 and Stn1, were found to physically associate with Spt5. This study proposes that Spt5 represents the target of the Cdc13-Stn1-Ten1 complex in transcription regulation.
      Title: The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription.
    4. Data support a model that Stn1 and Ten1 can function in a Cdc13-independent manner and have implications for the function of CST components across eukaryotes.
      Title: Interplay between nonsense-mediated mRNA decay and DNA damage response pathways reveals that Stn1 and Ten1 are the key CST telomere-cap components.
    5. Data show that by controlling the timing of Cdc13 and Stn1 phosphorylations, Cdk1 regulates the temporal recruitment of telomerase complexes and Cdc13-Stn1-Ten1 (CST) complexes to the telomeres to facilitate telomere maintenance.
      Title: Cdk1 regulates the temporal recruitment of telomerase and Cdc13-Stn1-Ten1 complex for telomere replication.
    6. Results emphasize that Cdc13 relies on Ten1 to execute its essential function, but leave open the possibility that Ten1 has a Cdc13-independent role in DNA replication.
      Title: TEN1 is essential for CDC13-mediated telomere capping.
    7. Ten1 protein interacts with Cdc13 protein to promote its telemeric TG(1-3) DNA-binding activity.
      Title: Ten1p promotes the telomeric DNA-binding activity of Cdc13p: implication for its function in telomere length regulation.
    8. Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates.
      Title: RPA-like proteins mediate yeast telomere function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription elongation factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables translation elongation factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere capping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in telomere capping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance via telomerase IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CST complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ten1p
    NP_013110.1
    • Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p; similar to human Ten1 which is critical for the telomeric function of the CST (Cdc13p-Stn1p-Ten1p) complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      167320..167802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181897.1 → NP_013110.1  TPA: Ten1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013110.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY12, Q07921
      UniProtKB/TrEMBL
      A7A0R5, B3LSY3, B5VMV2, C7GPE8, C8ZCY2, N1P7K7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07921.1

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