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    aldose 1-epimerase superfamily protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856617, updated on 9-Dec-2024

    Summary

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    Official Full Name
    aldose 1-epimerase superfamily protein
    Primary source
    SGD:S000001253
    Locus tag
    YHR210C
    See related
    AllianceGenome:SGD:S000001253; FungiDB:YHR210C; VEuPathDB:YHR210C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable aldose 1-epimerase activity. Predicted to be involved in galactose catabolic process via UDP-galactose and glucose metabolic process. Human ortholog(s) of this gene implicated in galactosemia 4. Orthologous to human GALM (galactose mutarotase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (520712..521737, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene branched-chain-amino-acid transaminase BAT1 Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene flocculin FLO5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UDPgalactose 4-epimerase from Saccharomyces cerevisiae. A bifunctional enzyme with aldose 1-epimerase activity. Majumdar S, et al. Eur J Biochem, 2004 Feb. PMID 14764091
    2. Investigation of the functional role of aldose 1-epimerase in engineered cellobiose utilization. Li S, et al. J Biotechnol, 2013 Oct 10. PMID 23954547
    3. Genome-wide transcriptional analysis of aerobic and anaerobic chemostat cultures of Saccharomyces cerevisiae. ter Linde JJ, et al. J Bacteriol, 1999 Dec. PMID 10601195, Free PMC Article
    4. Functional genetic discovery of enzymes using full-scan mass spectrometry metabolomics (1). Caudy AA, et al. Biochem Cell Biol, 2019 Feb. PMID 30001498
    5. Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes. del Alamo M, et al. PLoS Biol, 2011 Jul. PMID 21765803, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aldose 1-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose catabolic process via UDP-galactose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    aldose 1-epimerase superfamily protein
    NP_012080.3
    • Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      520712..521737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179341.3 → NP_012080.3  TPA: aldose 1-epimerase superfamily protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012080.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLF9, P38893
      UniProtKB/TrEMBL
      A6ZTB7, B3LSX1, C7GN95, N1P9J1
      Conserved Domains (1) summary
      cd09019
      Location:13 → 339
      galactose_mutarotase_like; galactose mutarotase_like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38893.1

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