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    CVM1 Cvm1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CVM1
    Official Full Name
    Cvm1p
    Primary source
    SGD:S000004770
    Locus tag
    YMR160W
    See related
    AllianceGenome:SGD:S000004770; FungiDB:YMR160W; VEuPathDB:YMR160W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in sphingolipid metabolic process. Located in fungal-type vacuole membrane. Is active in endoplasmic reticulum-vacuole membrane contact site; peroxisomal membrane; and vacuole-mitochondrion membrane contact site. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CVM1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (575066..577516)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Atg16p Neighboring gene type I HSP40 co-chaperone HLJ1 Neighboring gene aminophospholipid-translocating P4-type ATPase DNF3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cvm1 is a component of multiple vacuolar contact sites required for sphingolipid homeostasis. Bisinski DD, et al. J Cell Biol, 2022 Aug 1. PMID 35766971, Free PMC Article
    2. Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes. Bloom J, et al. J Biol Chem, 2011 Feb 18. PMID 21127052, Free PMC Article
    3. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Willingham S, et al. Science, 2003 Dec 5. PMID 14657499
    4. Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis. Mattiazzi Ušaj M, et al. Metallomics, 2015 Sep. PMID 26067383
    5. Elucidation of the interaction proteome of mitochondrial chaperone Hsp78 highlights its role in protein aggregation during heat stress. Jaworek W, et al. J Biol Chem, 2022 Oct. PMID 36115461, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cvm1 is a component of multiple vacuolar contact sites required for sphingolipid homeostasis.
      Title: Cvm1 is a component of multiple vacuolar contact sites required for sphingolipid homeostasis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in sphingolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum-vacuole membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in vacuole-mitochondrion membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cvm1p
    NP_013883.1
    • Protein involved in sphingolipid metabolism; localizes to vacuolar contact sites with mitochondria, ER and peroxisomes; mutant has enhanced sensitivity to overexpression of mutant huntingtin; relative distribution within the vacuolar membrane changes upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      575066..577516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182664.1 → NP_013883.1  TPA: Cvm1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013883.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZY2, Q03823
      UniProtKB/TrEMBL
      A6ZML9, B5VPT0, C7GU62, N1NYH3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03823.1

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