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    BIL2 Bil2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852869, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BIL2
    Official Full Name
    Bil2p
    Primary source
    SGD:S000002983
    Locus tag
    YGL015C
    See related
    AllianceGenome:SGD:S000002983; FungiDB:YGL015C; VEuPathDB:YGL015C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Acts upstream of or within negative regulation of formin-nucleated actin cable assembly and protein localization to mating projection tip. Located in secretory vesicle and site of polarized growth. Is active in cytosol and mating projection tip. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BIL2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (465043..465435, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene arginyltransferase Neighboring gene Kap122p Neighboring gene Puf4p Neighboring gene drug-responsive transcription factor PDR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The roles of yeast formins and their regulators Bud6 and Bil2 in the pheromone response. Magliozzi JO, et al. Mol Biol Cell, 2024 Jun 1. PMID 38656798, Free PMC Article
    2. Bil2 Is a Novel Inhibitor of the Yeast Formin Bnr1 Required for Proper Actin Cable Organization and Polarized Secretion. Rands TJ, et al. Front Cell Dev Biol, 2021. PMID 33634134, Free PMC Article
    3. A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. Proszynski TJ, et al. Proc Natl Acad Sci U S A, 2005 Dec 13. PMID 16330752, Free PMC Article
    4. Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity. Huang D, et al. Mol Cell Biol, 2002 Jul. PMID 12077337, Free PMC Article
    5. A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast. Lam C, et al. Eukaryot Cell, 2014 Mar. PMID 24390141, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of formin-nucleated actin cable assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to mating projection tip IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in prospore membrane HDA PubMed 
    located_in secretory vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in site of polarized growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Bil2p
    NP_011500.3
    • Formin inhibitor; inhibits Bnr1p-mediated actin filament nucleation but not elongation during vegetative growth; performs distinct but overlapping roles with Hof1p to control actin cable assembly and polarized secretion; spatially focuses Bni1p at mating projection tips, and with Bud6p organizes Bni1p into clusters that nucleate actin assembly during mating projection formation; bnr1 bil2 double mutants are inviable; localizes to the cytosol, secretory vesicles and sites of polarized growth

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      465043..465435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180880.3 → NP_011500.3  TPA: Bil2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011500.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUC2, P33199
      UniProtKB/TrEMBL
      A6ZUX8, B3LIN0, C7GSA9, C8Z8M7, G2WE78, N1P3C6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33199.1

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