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    MTW1 MIND complex subunit MTW1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MTW1
    Official Full Name
    MIND complex subunit MTW1
    Primary source
    SGD:S000000032
    Locus tag
    YAL034W-A
    See related
    AllianceGenome:SGD:S000000032; FungiDB:YAL034W-A; VEuPathDB:YAL034W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DSN3; NSL2
    Summary
    Involved in chromosome segregation and protein localization to kinetochore. Located in spindle pole. Part of MIS12/MIND type complex. Orthologous to human MIS12 (MIS12 kinetochore complex component). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MTW1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (79718..80587)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene GTP-binding protein RBG1 Neighboring gene translation initiation factor eIF5B Neighboring gene Fun19p Neighboring gene RNA-binding protein POP5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast. Goshima G, et al. Cell, 2000 Mar 17. PMID 10761928
    2. Temporal characterization of homology-independent centromere coupling in meiotic prophase. Obeso D, et al. PLoS One, 2010 Apr 23. PMID 20428251, Free PMC Article
    3. Control of the spindle checkpoint by lateral kinetochore attachment and limited Mad1 recruitment. Krefman NI, et al. Mol Biol Cell, 2015 Jul 15. PMID 26023090, Free PMC Article
    4. DNA topoisomerase II is a determinant of the tensile properties of yeast centromeric chromatin and the tension checkpoint. Warsi TH, et al. Mol Biol Cell, 2008 Oct. PMID 18701701, Free PMC Article
    5. Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins. Meraldi P, et al. Genome Biol, 2006. PMID 16563186, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MIS12/MIND type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MIS12/MIND type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MIND complex subunit MTW1
    NP_009367.1
    • Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      79718..80587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178179.1 → NP_009367.1  TPA: MIND complex subunit MTW1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009367.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPI3, P39731
      UniProtKB/TrEMBL
      A7A0D3, B3LUW9, C7GPK0, C8Z3F8, G2W8J7, N1P9S8
      Conserved Domains (1) summary
      pfam05859
      Location:11 → 145
      Mis12; Mis12 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39731.2

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