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    FUR1 uracil phosphoribosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856529, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FUR1
    Official Full Name
    uracil phosphoribosyltransferase
    Primary source
    SGD:S000001170
    Locus tag
    YHR128W
    See related
    AllianceGenome:SGD:S000001170; FungiDB:YHR128W; VEuPathDB:YHR128W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables uracil phosphoribosyltransferase activity. Involved in pyrimidine-containing compound salvage. Predicted to be located in cytoplasm. Orthologous to human UPRT (uracil phosphoribosyltransferase homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FUR1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (362115..362765)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Ans1p Neighboring gene uncharacterized protein Neighboring gene actin-related protein 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Baker's yeast UMP:pyrophosphate phosphoribosyltransferase. Purification, enzymatic and kinetic properties. Natalini P, et al. J Biol Chem, 1979 Mar 10. PMID 216696
    2. Regulation of the pyrimidine salvage pathway by the FUR1 gene product of Saccharomyces cerevisiae. Kern L, et al. Curr Genet, 1991 May. PMID 1913872
    3. Bisphosphonates activate the 5-fluorouracil/uracil phosphoribosyltransferase activity present in Saccharomyces cerevisiae cell extracts: implications for tumor treatments. Pérez-Zúñiga FJ, et al. Biochem Pharmacol, 2008 Oct 1. PMID 18706399
    4. Molecular mechanisms of primary resistance to flucytosine in Candida albicans. Hope WW, et al. Antimicrob Agents Chemother, 2004 Nov. PMID 15504867, Free PMC Article
    5. Codon-optimized glucoamylase sGAI of Aspergillus awamori improves starch utilization in an industrial yeast. Favaro L, et al. Appl Microbiol Biotechnol, 2012 Aug. PMID 22450569

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uracil phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uracil phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine-containing compound salvage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uracil phosphoribosyltransferase
    NP_011996.2
    • Uracil phosphoribosyltransferase; synthesizes UMP from uracil; involved in the pyrimidine salvage pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      362115..362765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179258.1 → NP_011996.2  TPA: uracil phosphoribosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011996.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL77, P18562
      UniProtKB/TrEMBL
      A6ZT35, B3LSP2, B5VK61, C7GR72, C8Z9S1, G2WFK1, N1P9F6
      Conserved Domains (1) summary
      pfam14681
      Location:14 → 214
      UPRTase; Uracil phosphoribosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18562.2

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