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    COQ11 ubiquinone biosynthesis protein COQ11 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850997, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COQ11
    Official Full Name
    ubiquinone biosynthesis protein COQ11
    Primary source
    SGD:S000004281
    Locus tag
    YLR290C
    See related
    AllianceGenome:SGD:S000004281; FungiDB:YLR290C; VEuPathDB:YLR290C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MRX2
    Summary
    Involved in ubiquinone-6 biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COQ11 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (717145..717978, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Mec3p Neighboring gene GTPase GUF1 Neighboring gene translation initiation factor eIF2B subunit beta Neighboring gene Sec63 complex subunit SEC72

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nonfunctional coq10 mutants maintain the ERMES complex and reveal true phenotypes associated with the loss of the coenzyme Q chaperone protein Coq10. Novales NA, et al. J Biol Chem, 2024 Nov. PMID 39343004, Free PMC Article
    2. COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10. Bradley MC, et al. J Biol Chem, 2020 May 1. PMID 32205446, Free PMC Article
    3. Coenzyme Q biosynthetic proteins assemble in a substrate-dependent manner into domains at ER-mitochondria contacts. Subramanian K, et al. J Cell Biol, 2019 Apr 1. PMID 30674579, Free PMC Article
    4. Functional genetic discovery of enzymes using full-scan mass spectrometry metabolomics (1). Caudy AA, et al. Biochem Cell Biol, 2019 Feb. PMID 30001498
    5. Assessing systems properties of yeast mitochondria through an interaction map of the organelle. Perocchi F, et al. PLoS Genet, 2006 Oct 20. PMID 17054397, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10.
      Title: COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone-6 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquinone biosynthesis protein COQ11
    NP_013393.1
    • Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes; required for synthesis of wild-type levels of Coenzyme Q (ubiquinone); member of the short-chain dehydrogenase/reductase (SDR) superfamily; orthologous gene in some other fungi is fused to the COQ10 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      717145..717978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182178.1 → NP_013393.1  TPA: ubiquinone biosynthesis protein COQ11 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013393.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYT6, Q05892
      UniProtKB/TrEMBL
      A7A1H3, B3RHH0, C7GVU7, C8ZDQ4, G2WJB4, N1P718
      Conserved Domains (2) summary
      COG0702
      Location:3 → 83
      YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]
      cl21454
      Location:7 → 204
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05892.1

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