Uchl5 ubiquitin carboxyl-terminal esterase L5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uchl5provided by MGI
Official Full Name: ubiquitin carboxyl-terminal esterase L5provided by MGI
Primary source: MGI:MGI:1914848
See related: Ensembl:ENSMUSG00000018189 AllianceGenome:MGI:1914848
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Uch37; 5830413B11Rik
Summary: Predicted to enable cysteine-type deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Involved in several processes, including brain development; positive regulation of DNA metabolic process; and telomere maintenance. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of Ino80 complex and cytosolic proteasome complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; nose; and salivary gland primordium. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14 (RPKM 10.8), placenta adult (RPKM 8.5) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 F; 1 62.54 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (143652993..143683204)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (143777234..143807466)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome.
Title: METTL14/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome.
NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs.
Title: NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs.
Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency.
Title: Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency.
PI3K-dependent UCHL5 is required for high glucose-induced TGF-betaR1 protein expression in mesangial cells. UCHL5 is also required for high glucose-induced TGF-betaR1 protein deubiquitination, p21(WAF1) and fibronectin protein expression and cell hypertrophy.
Title: Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-β receptor I expression and hypertrophy in mesangial cells.
ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 to activate ATP hydrolysis and enhance their own destruction
Title: Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs.
this is the first report characterizing the physiological roles of Uch37 and Rpn13 in murine development and implicating a non-ATPase proteasomal protein, Rpn13, in the process of gametogenesis
Title: Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type deubiquitinase activity	TAS Traceable Author Statement more info
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables proteasome binding	IEA Inferred from Electronic Annotation more info
enables proteasome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA recombination	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in forebrain morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA strand elongation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Ino80 complex	ISO Inferred from Sequence Orthology more info
part_of Ino80 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic proteasome complex	IEA Inferred from Electronic Annotation more info
part_of cytosolic proteasome complex	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase isozyme L5

Names: UCH-L5; ubiquitin C-terminal hydrolase 37; ubiquitin C-terminal hydrolase UCH37; ubiquitin thioesterase L5

NP_001153338.1

EC 3.4.19.12

NP_062508.2

EC 3.4.19.12

XP_006529823.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159866.1 → NP_001153338.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2

See identical proteins and their annotated locations for NP_001153338.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AK017925, BY279731

Consensus CDS

CCDS78699.1

UniProtKB/Swiss-Prot

Q9WUP7

Related

ENSMUSP00000018333.8, ENSMUST00000018333.13

Conserved Domains (2) summary

cd02255
Location:8 → 223

Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

pfam18031
Location:263 → 308

UCH_C; Ubiquitin carboxyl-terminal hydrolases
NM_019562.2 → NP_062508.2 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1

See identical proteins and their annotated locations for NP_062508.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF148447, AL592403, BY279731

Consensus CDS

CCDS15346.1

UniProtKB/Swiss-Prot

Q9CVJ4, Q9CXZ3, Q9R107, Q9WUP7

Related

ENSMUSP00000140106.2, ENSMUST00000189936.7

Conserved Domains (2) summary

cd02255
Location:8 → 223

Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

pfam18031
Location:264 → 309

UCH_C; Ubiquitin carboxyl-terminal hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

143652993..143683204

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529760.5 → XP_006529823.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

Conserved Domains (2) summary

cd02255
Location:8 → 223

Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1

pfam18031
Location:264 → 309

UCH_C; Ubiquitin carboxyl-terminal hydrolases