Hars1 histidyl-tRNA synthetase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hars1provided by MGI
Official Full Name: histidyl-tRNA synthetase 1provided by MGI
Primary source: MGI:MGI:108087
See related: Ensembl:ENSMUSG00000001380 AllianceGenome:MGI:108087
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hars; MMHRS
Summary: Predicted to enable several functions, including ATP binding activity; histidine-tRNA ligase activity; and protein homodimerization activity. Predicted to be involved in histidyl-tRNA aminoacylation and mitochondrial translation. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease, axonal type 2W and Usher syndrome type 3B. Orthologous to human HARS1 (histidyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 39.6), liver E14.5 (RPKM 33.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B2; 18 19.46 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (36899581..36916258, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (36766528..36783205, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AA 60-90 of HRS were absolutely required for in vitro as well as in vivo signaling via MyD88-dependent TLR pathways to case myositis.
Title: Functional redundancy of MyD88-dependent signaling pathways in a murine model of histidyl-transfer RNA synthetase-induced myositis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143518 (e-PCR)
- UniSTS:232764

Hars (e-PCR), detects polymorphism
- UniSTS:143316

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables histidine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histidine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables histidine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in histidyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in histidyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in histidyl-tRNA aminoacylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: histidine--tRNA ligase, cytoplasmic

Names: hisRS; histidine tRNA ligase; histidyl-tRNA synthetase, cytoplasmic

NP_032240.3

EC 6.1.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008214.4 → NP_032240.3 histidine--tRNA ligase, cytoplasmic

See identical proteins and their annotated locations for NP_032240.3

Status: VALIDATED

Source sequence(s)

AI849599, AK166826, CA561201

Consensus CDS

CCDS29164.1

UniProtKB/Swiss-Prot

Q3TKU3, Q61035

UniProtKB/TrEMBL

Q3U890, Q3UDH1

Related

ENSMUSP00000001416.7, ENSMUST00000001416.8

Conserved Domains (4) summary

COG0124
Location:56 → 501

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

cd00773
Location:69 → 394

HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...

cd00859
Location:408 → 499

HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

cd00938
Location:5 → 49

HisRS_RNA; HisRS_RNA binding domain. This short RNA-binding domain is found at the N-terminus of HisRS in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). This domain consists of a helix- turn- helix structure, which is similar to other RNA-binding ...