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    Ccrl2 C-C motif chemokine receptor-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 54199, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccrl2provided by MGI
    Official Full Name
    C-C motif chemokine receptor-like 2provided by MGI
    Primary source
    MGI:MGI:1920904
    See related
    Ensembl:ENSMUSG00000043953 AllianceGenome:MGI:1920904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E01; Ackr5; CCR11; L-CCR; Cmkbr1l2; 1810047I05Rik
    Summary
    Enables chemokine receptor binding activity. Involved in inflammatory response. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Orthologous to human CCRL2 (C-C motif chemokine receptor like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 16.6), placenta adult (RPKM 10.7) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccrl2 in Genome Data Viewer
    Location:
    9 F2; 9 60.92 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110883902..110886586, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (111054834..111057518, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene receptor transporter protein 3 Neighboring gene predicted gene 10030 Neighboring gene lactotransferrin Neighboring gene STARR-seq mESC enhancer starr_25285 Neighboring gene STARR-seq mESC enhancer starr_25286 Neighboring gene ribosomal protein L31, pseudogene 19 Neighboring gene predicted gene, 26409

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway. Chen L, et al. Int Heart J, 2024. PMID 38556341
    2. Induction of glial L-CCR mRNA expression in spinal cord and brain in experimental autoimmune encephalomyelitis. Brouwer N, et al. Glia, 2004 Apr 1. PMID 14999816
    3. Nonredundant role of CCRL2 in lung dendritic cell trafficking. Otero K, et al. Blood, 2010 Oct 21. PMID 20606167, Free PMC Article
    4. Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8. Biber K, et al. J Leukoc Biol, 2003 Aug. PMID 12885941
    5. LPS-induced expression of a novel chemokine receptor (L-CCR) in mouse glial cells in vitro and in vivo. Zuurman MW, et al. Glia, 2003 Mar. PMID 12555200

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway.
      Title: Role of CCRL2 in the Pathogenesis of Experimental Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3 Pathway.
    2. Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent beta2 integrin activation in monocytes.
      Title: Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes.
    3. Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function.
      Title: Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function.
    4. CCRL2 promotes antitumor T-cell immunity via amplifying TLR4-mediated immunostimulatory macrophage activation.
      Title: CCRL2 promotes antitumor T-cell immunity via amplifying TLR4-mediated immunostimulatory macrophage activation.
    5. The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance.
      Title: The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance.
    6. Ccrl2 modulates chemerin levels in the epithelial lining fluid of the lungs but does not contribute to the development of O3-induced lung pathology.
      Title: Chemokine (C-C Motif) Receptor-Like 2 is not essential for lung injury, lung inflammation, or airway hyperresponsiveness induced by acute exposure to ozone.
    7. upregulation of CCRL2 observed under inflammatory conditions is functional to finely tune CXCR2-mediated neutrophil recruitment at sites of inflammation.
      Title: The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage.
    8. chemokine (CC motif) receptor-like 2 should be considered to be a molecule involved in the regulation of the inflammatory response associated with multiple sclerosis.
      Title: CCRL2 regulates M1/M2 polarization during EAE recovery phase.
    9. CCRL2 mRNA was not significantly changed in murine and human non-alcoholic steatohepatitis liver. CCRL2 was related to the mRNA levels of F4/80, transforming growth factor beta and alpha smooth muscle actin in murine non-alcoholic steatohepatitis.
      Title: Chemokine (CC-motif) receptor-like 2 mRNA is expressed in hepatic stellate cells and is positively associated with characteristics of non-alcoholic steatohepatitis in mice and men.
    10. Proinflammatory stimuli upregulate atypical chemerin receptor CCRL2 and VCAM-1 on endothelial cells via NF-kappaB and JAK/STAT intracellular signaling pathways.
      Title: Expression, regulation, and function of atypical chemerin receptor CCRL2 on endothelial cells.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables C-C chemokine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables CCR chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chemokine receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    C-C chemokine receptor-like 2
    Names
    G-protein coupled beta chemokine receptor
    chemokine (C-C motif) receptor-like 2
    chemokine (C-C) receptor 1-like 2
    chemokine receptor CCR11
    lipopolysaccharide inducible C-C chemokine receptor related
    lipopolysaccharide-inducible C-C chemokine receptor
    lipopolysacharide-inducible C-C chemokine receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302376.1 → NP_001289305.1  C-C chemokine receptor-like 2

      See identical proteins and their annotated locations for NP_001289305.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK007808, AK145946, BC038631, BY162594
      Consensus CDS
      CCDS23582.1
      UniProtKB/Swiss-Prot
      O35457, O70171, Q3UKM6, Q4FK04, Q91YD7
      Related
      ENSMUSP00000143116.2, ENSMUST00000199839.5
      Conserved Domains (1) summary
      cd15171
      Location:38 → 316
      7tmA_CCRL2; CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001302377.1 → NP_001289306.1  C-C chemokine receptor-like 2

      See identical proteins and their annotated locations for NP_001289306.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC118727, AK007808, AK145946, BC038631, BY162594
      Consensus CDS
      CCDS23582.1
      UniProtKB/Swiss-Prot
      O35457, O70171, Q3UKM6, Q4FK04, Q91YD7
      Conserved Domains (1) summary
      cd15171
      Location:38 → 316
      7tmA_CCRL2; CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_017466.5 → NP_059494.2  C-C chemokine receptor-like 2

      See identical proteins and their annotated locations for NP_059494.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK007808, AK145946, BC038631
      Consensus CDS
      CCDS23582.1
      UniProtKB/Swiss-Prot
      O35457, O70171, Q3UKM6, Q4FK04, Q91YD7
      Related
      ENSMUSP00000107519.2, ENSMUST00000111888.3
      Conserved Domains (1) summary
      cd15171
      Location:38 → 316
      7tmA_CCRL2; CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      110883902..110886586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35457.2 GenPept UniProtKB/Swiss-Prot:O35457

    Gene LinkOut

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