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    Il18bp interleukin 18 binding protein [ Mus musculus (house mouse) ]

    Gene ID: 16068, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il18bpprovided by MGI
    Official Full Name
    interleukin 18 binding proteinprovided by MGI
    Primary source
    MGI:MGI:1333800
    See related
    Ensembl:ENSMUSG00000070427 AllianceGenome:MGI:1333800
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MC54L; Igifbp; IL-18BP
    Summary
    Predicted to enable interleukin-18 binding activity. Predicted to be involved in T-helper 1 type immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in gut; liver; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in allergic contact dermatitis and myocardial infarction. Orthologous to human IL18BP (interleukin 18 binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 16.5), liver E18 (RPKM 14.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Il18bp in Genome Data Viewer
    Location:
    7 E2; 7 54.71 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101664281..101669699, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102015074..102018232, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8193 Neighboring gene nuclear mitotic apparatus protein 1 Neighboring gene MYST histone acetyltransferase 1 pseudogene Neighboring gene predicted gene, 39061 Neighboring gene ring finger protein 121 Neighboring gene STARR-seq mESC enhancer starr_19703 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2 Neighboring gene ADP-ribosyltransferase 5 Neighboring gene ADP-ribosyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IL-18 Binding Protein-Producing Cells Attenuate Anemia in Murine Macrophage Activation Syndrome. Harel M, et al. J Immunol, 2023 Jun 1. PMID 37074208, Free PMC Article
    2. Production of IL-18 Binding Protein by Radiosensitive and Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome. Harel M, et al. J Immunol, 2020 Aug 15. PMID 32651219
    3. Interleukin 18 binding protein (IL18-BP) inhibits neointimal hyperplasia after balloon injury in an atherosclerotic rabbit model. Li JM, et al. J Vasc Surg, 2008 May. PMID 18455646
    4. Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein. Banda NK, et al. J Immunol, 2003 Feb 15. PMID 12574381
    5. The protective role of interleukin-18 binding protein in a murine model of cardiac ischemia/reperfusion injury. Gu H, et al. Transpl Int, 2015 Dec. PMID 26340315

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-18 Binding Protein-Producing Cells Attenuate Anemia in Murine Macrophage Activation Syndrome.
      Title: IL-18 Binding Protein-Producing Cells Attenuate Anemia in Murine Macrophage Activation Syndrome.
    2. Production of IL-18 Binding Protein by Radiosensitive and Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome.
      Title: Production of IL-18 Binding Protein by Radiosensitive and Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome.
    3. IL-18BP possessed protective effect against LPS-induced ALI, which might be associated with its regulation of NF-kappaB and Nrf2 activities.
      Title: Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway.
    4. asthma is very likely to be determined by balance of IL-18/IL-18BP/IL-18R expression in inflammatory cells.
      Title: Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R.
    5. IL-18BP ameliorates cardiac ischemia/reperfusion injury in part through suppression of Th17 differentiation.
      Title: The protective role of interleukin-18 binding protein in a murine model of cardiac ischemia/reperfusion injury.
    6. Data show that IL-18bp acts as a sensor for IFN-gamma and can regulate both Th1 and Th17 responses in the CNS.
      Title: Inflammation in the central nervous system and Th17 responses are inhibited by IFN-gamma-Induced IL-18 binding protein.
    7. IL-18 and IL-18BP may have roles in testicular development, and also in the regulation of testicular functions under physiological conditions
      Title: Constitutive expression of IL-18 binding protein in murine testicular tissues and cells.
    8. A single intravenous dose of recombinant mouse IL18BP decreased neointimal hyperplasia and improved arterial L/A ratios in an atherosclerotic balloon-injury animal model.
      Title: Interleukin 18 binding protein (IL18-BP) inhibits neointimal hyperplasia after balloon injury in an atherosclerotic rabbit model.
    9. Administratioan of murine IL-18BP at the time of the booster injection of bovine CII reduces the progressive severity of collagen-induced arthritis; both clinical disease activity and histological scores are decreased by 50%.
      Title: Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein.
    10. functional polarization of Ag-specific CD4(+) Th2 cells entering the CNS during the accelerating phase of experimental autoimmune encephalomyelitis is flexible and dependent on IL-18, which is overturned by IL-18 binding protein
      Title: Targeted overexpression of IL-18 binding protein at the central nervous system overrides flexibility in functional polarization of antigen-specific Th2 cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables interleukin-18 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-18 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-18 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in T-helper 1 type immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in T-helper 1 type immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T-helper 1 type immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-18-binding protein
    Names
    interferon gamma-inducing factor-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363982.1 → NP_001350911.1  interleukin-18-binding protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240, AK003370
      Consensus CDS
      CCDS21522.1
      UniProtKB/Swiss-Prot
      Q4FJR8, Q4FK87, Q9CV30, Q9QUH2, Q9Z0M9, Q9Z0N0
      Related
      ENSMUSP00000091685.4, ENSMUST00000094134.5
      Conserved Domains (1) summary
      cl23951
      Location:47 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    2. NM_001382458.1 → NP_001369387.1  interleukin-18-binding protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      Q4FJR8, Q4FK87, Q9CV30, Q9QUH2, Q9Z0M9, Q9Z0N0
      Conserved Domains (1) summary
      cl23951
      Location:47 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    3. NM_010531.2 → NP_034661.1  interleukin-18-binding protein precursor

      See identical proteins and their annotated locations for NP_034661.1

      Status: VALIDATED

      Source sequence(s)
      AC167240, AF122907
      Consensus CDS
      CCDS21522.1
      UniProtKB/Swiss-Prot
      Q4FJR8, Q4FK87, Q9CV30, Q9QUH2, Q9Z0M9, Q9Z0N0
      Related
      ENSMUSP00000148080.2, ENSMUST00000209844.2
      Conserved Domains (1) summary
      cl23951
      Location:47 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101664281..101669699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242160.2 → XP_030098020.1  interleukin-18-binding protein isoform X2

      UniProtKB/Swiss-Prot
      Q4FJR8, Q4FK87, Q9CV30, Q9QUH2, Q9Z0M9, Q9Z0N0
      Conserved Domains (1) summary
      cl23951
      Location:47 → 169
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein

    2. XM_036152698.1 → XP_036008591.1  interleukin-18-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A1B0GT50
      Related
      ENSMUSP00000148201.2, ENSMUST00000209368.2
      Conserved Domains (1) summary
      cl23951
      Location:47 → 164
      Pox_vIL-18BP; Orthopoxvirus interleukin 18 binding protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0M9.2 GenPept UniProtKB/Swiss-Prot:Q9Z0M9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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