Yaf2 YY1 associated factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Yaf2provided by MGI
Official Full Name: YY1 associated factor 2provided by MGI
Primary source: MGI:MGI:1914307
See related: Ensembl:ENSMUSG00000022634 AllianceGenome:MGI:1914307
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810021M11Rik
Summary: Predicted to enable DNA binding activity; transcription coactivator activity; and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including cranial ganglion; early conceptus; embryo mesenchyme; genitourinary system; and neural ectoderm. Orthologous to human YAF2 (YY1 associated factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 27.2), frontal lobe adult (RPKM 27.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 47.39 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (93181714..93234816, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (93283833..93336935, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells.
Title: Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells.
The results suggest that histone H1-dependent chromatin compaction plays a critical role in the stable propagation of H2AK119ub1 by RYBP/YAF2-PRC1 during cell division.
Title: RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division.
Yaf2 acts as a functional, likely molecular, link between YY1 and the Polycomb proteins. It is proposed to mediate the DNA binding activity of YY1 and recruitment of Polycomb proteins to the regulatory region of target genes.
Title: PcG recruitment by the YY1 REPO domain can be mediated by Yaf2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237380

Yaf2 (e-PCR), detects polymorphism
- UniSTS:498529

Yaf2 (e-PCR), detects polymorphism
- UniSTS:498805

RH143357 (e-PCR)
- UniSTS:232604

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: YY1-associated factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024189.6 → NP_077151.3 YY1-associated factor 2

See identical proteins and their annotated locations for NP_077151.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and is protein-coding.

Source sequence(s)

AK011702, AK148634

Consensus CDS

CCDS27765.1

UniProtKB/Swiss-Prot

Q3UFD4, Q99LW6, Q9DBE4

Related

ENSMUSP00000079179.7, ENSMUST00000080299.7

Conserved Domains (2) summary

sd00029
Location:23 → 42

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:20 → 43

zf-RanBP; Zn-finger in Ran binding protein and others

RNA

NR_028315.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate exon resulting in a frameshift and early stop codon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK011702, AK148634

Related

ENSMUST00000133736.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

93181714..93234816 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521292.4 → XP_006521355.1 YY1-associated factor 2 isoform X1

Conserved Domains (3) summary

sd00029
Location:23 → 42

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:20 → 43

zf-RanBP; Zn-finger in Ran binding protein and others

pfam17219
Location:126 → 156

YAF2_RYBP; Yaf2/RYBP C-terminal binding motif