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    Ucp2 uncoupling protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54315, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ucp2provided by RGD
    Official Full Name
    uncoupling protein 2provided by RGD
    Primary source
    RGD:3932
    See related
    AllianceGenome:RGD:3932
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including C4-dicarboxylate transmembrane transporter activity; GDP binding activity; and inorganic anion transmembrane transporter activity. Involved in several processes, including cellular response to lead ion; liver regeneration; and negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in mitochondrial membrane. Used to study hypertension; metabolic dysfunction-associated steatotic liver disease; transient cerebral ischemia; and type 2 diabetes mellitus. Biomarker of congestive heart failure; hypothyroidism; obstructive jaundice; steatotic liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carotid artery disease; diabetic neuropathy; end stage renal disease; hypertension; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 922.5), Heart (RPKM 460.9) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ucp2 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (164251373..164257742)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (154839242..154845612)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (165506375..165512744)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene C2 domain containing 3 centriole elongation regulator Neighboring gene uncharacterized LOC120099892 Neighboring gene uncoupling protein 3 Neighboring gene uncharacterized LOC103691200 Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene uncharacterized LOC120099893

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-aspartate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-aspartate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chloride transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables malate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables malate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables oxaloacetate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxaloacetate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables oxidative phosphorylation uncoupler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphate ion uniporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphate ion uniporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables proton transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables proton transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables secondary active sulfate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables secondary active sulfate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in C4-dicarboxylate transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in C4-dicarboxylate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in L-aspartate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adaptive thermogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to amino acid starvation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucose stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to lead ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glutamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in long-chain fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macrophage differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in malate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oxaloacetate(2-) transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reactive oxygen species metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cold IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to dexamethasone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to superoxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dicarboxylate carrier UCP2
    Names
    UCP 2
    Uncoupling protein 2, mitochondrial
    dicarboxylate carrier SLC25A8
    mitochondrial uncoupling protein 2
    solute carrier family 25 member 8
    uncoupling protein 2 (mitochondrial, proton carrier)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019354.3NP_062227.2  dicarboxylate carrier UCP2

      Status: VALIDATED

      Source sequence(s)
      AB006613, FQ227097
      UniProtKB/Swiss-Prot
      O70178, O88183, P56500, Q6GST1
      UniProtKB/TrEMBL
      A6I6P2
      Conserved Domains (1) summary
      pfam00153
      Location:112206
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      164251373..164257742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)