Lif LIF, interleukin 6 family cytokine [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lifprovided by RGD
Official Full Name: LIF, interleukin 6 family cytokineprovided by RGD
Primary source: RGD:620865
See related: EnsemblRapid:ENSRNOG00000007002 AllianceGenome:RGD:620865
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables leukemia inhibitory factor receptor binding activity. Involved in several processes, including negative regulation of angiogenesis; positive regulation of corticotropin secretion; and transdifferentiation. Located in extracellular space. Biomarker of brain ischemia and congestive heart failure. Orthologous to human LIF (LIF interleukin 6 family cytokine). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 4.7), Lung (RPKM 4.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (83354602..83364053)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (79131049..79140486)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (84482652..84500574)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Poststroke Peripheral Immune Response Is Differentially Regulated by Leukemia Inhibitory Factor in Aged Male and Female Rodents.
Title: The Poststroke Peripheral Immune Response Is Differentially Regulated by Leukemia Inhibitory Factor in Aged Male and Female Rodents.
blood-derived vitronectin (VTN) rapidly and potently activates leukemia inhibitory factor (LIF) and pro-inflammatory interleukin 6 (IL-6) in vitro and after vascular injury in the brain.
Title: Blood vitronectin is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.
leukemia inhibitory factor is a key injury-induced cytokine that is stimulating the regenerative response of neural stem/progenitors
Title: Astrocyte-produced leukemia inhibitory factor expands the neural stem/progenitor pool following perinatal hypoxia-ischemia.
The expression levels of LIF and LIFR were increased following acute ocular hypertension.
Title: Expression of leukemia inhibitory factor in the rat retina following acute ocular hypertension.
H2O2-induced redox signaling increases Lif transcript levels through ILF3 mediated mRNA stabilization. Generation of H2O2 by injured photoreceptors may enhance stability of Lif mRNA and augment neuroprotective LIF signaling during degenerative conditions
Title: Expression of leukemia inhibitory factor in Müller glia cells is regulated by a redox-dependent mRNA stability mechanism.
Study shows that LIF-treated postmitotic oligodendrocytes secrete a number of neuropeptides at the mRNA and peptide level, and confirm LIF-induced galanin synthesis and secretion in primary rat oligodendrocytes but not in astrocytes
Title: Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor.
LIF mRNA and LIF protein expression in astrocytes show a trend of initial increase followed by steady decline in neonatal rats with periventricular leukomalacia (PVL).
Title: [Expression of endogenous leukemia inhibitory factor in neonatal rats with periventricular leukomalacia].
Expression of Lif in the injured retina and activation of the endogenous survival pathway involve signaling through p38 MAPK.
Title: p38 MAPK signaling acts upstream of LIF-dependent neuroprotection during photoreceptor degeneration.
LIF-induced JAK1-STAT3 signaling in cardiac myocytes is attenuated by depletion of the anti-oxidant glutathione.
Title: Depletion of cellular glutathione modulates LIF-induced JAK1-STAT3 signaling in cardiac myocytes.
Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes, showing that STAT3 signaling is redox-sensitive
Title: Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables leukemia inhibitory factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables leukemia inhibitory factor receptor binding	IEA Inferred from Electronic Annotation more info
enables leukemia inhibitory factor receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables leukemia inhibitory factor receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in animal organ regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood vessel remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway via STAT	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in decidualization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within decidualization	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryo implantation	ISO Inferred from Sequence Orthology more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in leukemia inhibitory factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukemia inhibitory factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in leukemia inhibitory factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in lung lobe morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung lobe morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lung vasculature development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maternal process involved in female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in meiotic nuclear division	IEA Inferred from Electronic Annotation more info
acts_upstream_of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in muscle organ morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hormone secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of meiotic nuclear division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in neuron development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of astrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of corticotropin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via STAT	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of metanephric nephron tubule epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of metanephric nephron tubule epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in retina development in camera-type eye	IDA Inferred from Direct Assay more info	PubMed
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in spongiotrophoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spongiotrophoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in transdifferentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trophoblast giant cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trophoblast giant cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leukemia inhibitory factor

Names: cholinergic neuronal differentiation factor; leukemia inhibitory factor (cholinergic differentiation factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022196.3 → NP_071532.2 leukemia inhibitory factor precursor

See identical proteins and their annotated locations for NP_071532.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P17777

UniProtKB/TrEMBL

A6IKF9, F7FFY1, O88211

Related

ENSRNOP00000009313.3, ENSRNOT00000009313.6

Conserved Domains (1) summary

smart00080
Location:34 → 191

LIF_OSM; leukemia inhibitory factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

83354602..83364053

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251364.5 → XP_006251426.1 leukemia inhibitory factor isoform X1

See identical proteins and their annotated locations for XP_006251426.1

UniProtKB/Swiss-Prot

P17777

UniProtKB/TrEMBL

A6IKF9, F7FFY1, O88211

Conserved Domains (1) summary

smart00080
Location:34 → 191

LIF_OSM; leukemia inhibitory factor
XM_039092388.1 → XP_038948316.1 leukemia inhibitory factor isoform X1

UniProtKB/Swiss-Prot

P17777

UniProtKB/TrEMBL

A6IKF9, F7FFY1, O88211

Conserved Domains (1) summary

smart00080
Location:34 → 191

LIF_OSM; leukemia inhibitory factor
XM_008770359.4 → XP_008768581.1 leukemia inhibitory factor isoform X2

Conserved Domains (1) summary

smart00080
Location:1 → 147

LIF_OSM; leukemia inhibitory factor