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    Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81921, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sh3gl3provided by RGD
    Official Full Name
    SH3 domain containing GRB2 like 3, endophilin A3provided by RGD
    Primary source
    RGD:620578
    See related
    EnsemblRapid:ENSRNOG00000019776 AllianceGenome:RGD:620578
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SH3P13; Sh3d2c1
    Summary
    Predicted to enable identical protein binding activity. Involved in negative regulation of clathrin-dependent endocytosis and positive regulation of neuron differentiation. Located in acrosomal vesicle; early endosome; and presynapse. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and postsynaptic endosome. Orthologous to human SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 203.2), Brain (RPKM 119.5) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sh3gl3 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (145533728..145664881)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (136124500..136255669)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (144069641..144200402)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556513 Neighboring gene basonuclin zinc finger protein 1 Neighboring gene uncharacterized LOC134483749 Neighboring gene uncharacterized LOC134483750 Neighboring gene U6 snRNA-associated Sm-like protein LSm5 Neighboring gene ADAMTS-like 3 Neighboring gene stabilizer of axonemal microtubules 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of rtSH3p13 gene encoding a development protein involved in vesicular traffic in spermiogenesis. Qiao Y, et al. Cell Res, 2004 Jun. PMID 15225413
    2. Inhibitory role of endophilin 3 in receptor-mediated endocytosis. Sugiura H, et al. J Biol Chem, 2004 May 28. PMID 15066995
    3. Identification of endophilins 1 and 3 as selective binding partners for VGLUT1 and their co-localization in neocortical glutamatergic synapses: implications for vesicular glutamate transporter trafficking and excitatory vesicle formation. De Gois S, et al. Cell Mol Neurobiol, 2006 Jul-Aug. PMID 16710756
    4. Endophilin isoforms have distinct characteristics in interactions with N-type Ca2+ channels and dynamin I. Tian Q, et al. Neurosci Bull, 2012 Oct. PMID 22961472, Free PMC Article
    5. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Voglmaier SM, et al. Neuron, 2006 Jul 6. PMID 16815333

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endophilin III binding to N-type Ca2+ channel carboxy-terminal fragments is Ca2+-independent in clathrin-mediated endocytosis.
      Title: Endophilin isoforms have distinct characteristics in interactions with N-type Ca2+ channels and dynamin I.
    2. VGLUT1 and endophilins 1 and 3 may interact to play an important role affecting the vesicular sequestration and synaptic release of glutamate.
      Title: Identification of endophilins 1 and 3 as selective binding partners for VGLUT1 and their co-localization in neocortical glutamatergic synapses: implications for vesicular glutamate transporter trafficking and excitatory vesicle formation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle uncoating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density, intracellular component IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic endosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    endophilin-A3
    Names
    SH3 domain protein 2 C1
    SH3 domain protein 2C
    SH3 domain-containing GRB2-like 3
    SH3 domain-containing GRB2-like protein 3
    SH3-domain GRB2-like 3
    endophilin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414376.1 → NP_001401305.1  endophilin-A3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O35104, O35180
      UniProtKB/TrEMBL
      A6JCJ2
      Related
      ENSRNOP00000095576.1, ENSRNOT00000096616.2

    2. NM_031238.3 → NP_112517.1  endophilin-A3 isoform 2

      See identical proteins and their annotated locations for NP_112517.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8L2R634, A0A9K3Y7M5, F1M8F8, Q9JKT0
      Related
      ENSRNOP00000026870.5, ENSRNOT00000026870.8
      Conserved Domains (2) summary
      cd11803
      Location:253 → 307
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
      cl12013
      Location:1 → 212
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      145533728..145664881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275380.1 → XP_063131450.1  endophilin-A3 isoform X8

    2. XM_063275376.1 → XP_063131446.1  endophilin-A3 isoform X6

    3. XM_063275373.1 → XP_063131443.1  endophilin-A3 isoform X4

    4. XM_063275370.1 → XP_063131440.1  endophilin-A3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AFE3
      Related
      ENSRNOP00000091889.1, ENSRNOT00000109733.2

    5. XM_063275385.1 → XP_063131455.1  endophilin-A3 isoform X9

    6. XM_063275378.1 → XP_063131448.1  endophilin-A3 isoform X7

    7. XM_006229481.5 → XP_006229543.1  endophilin-A3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6APE5, A0A8L2R634
      Related
      ENSRNOP00000095776.1, ENSRNOT00000119037.2
      Conserved Domains (2) summary
      cd07615
      Location:23 → 245
      BAR_Endophilin_A3; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A3
      cd11803
      Location:286 → 340
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

    8. XM_006229483.5 → XP_006229545.1  endophilin-A3 isoform X3

      See identical proteins and their annotated locations for XP_006229545.1

      UniProtKB/TrEMBL
      A0A8L2R634, A0A9K3Y7M5, F1M8F8, Q9JKT0
      Conserved Domains (2) summary
      cd11803
      Location:253 → 307
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
      cl12013
      Location:1 → 212
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    9. XM_006229485.3 → XP_006229547.1  endophilin-A3 isoform X5

      See identical proteins and their annotated locations for XP_006229547.1

      UniProtKB/TrEMBL
      A0A8L2R634
      Related
      ENSRNOP00000072673.2, ENSRNOT00000079989.3
      Conserved Domains (2) summary
      cd11803
      Location:219 → 273
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
      cl12013
      Location:1 → 178
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    10. XM_006229486.4 → XP_006229548.1  endophilin-A3 isoform X10

      Conserved Domains (2) summary
      cd11803
      Location:165 → 219
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
      cl12013
      Location:1 → 124
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    11. XM_063275400.1 → XP_063131470.1  endophilin-A3 isoform X10

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35180.2 GenPept UniProtKB/Swiss-Prot:O35180

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