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    Prdx6 peroxiredoxin 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94167, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prdx6provided by RGD
    Official Full Name
    peroxiredoxin 6provided by RGD
    Primary source
    RGD:71005
    See related
    EnsemblRapid:ENSRNOG00000081976 AllianceGenome:RGD:71005
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LPCAT-5
    Summary
    Enables 1-acylglycerophosphocholine O-acyltransferase activity and glutathione peroxidase activity. Involved in hydrogen peroxide catabolic process. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be active in cytosol. Orthologous to human PRDX6 (peroxiredoxin 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 1481.6), Heart (RPKM 904.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Prdx6 in Genome Data Viewer
    Location:
    13q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (76062082..76072631, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (73528746..73539295, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (79077567..79088113, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 45 Neighboring gene testis expressed 50 Neighboring gene solute carrier family 9, member C2 (putative) Neighboring gene uncharacterized LOC102552207 Neighboring gene actin, gamma 1, pseudogene 4 Neighboring gene glutaminyl-tRNA amidotransferase subunit QRSL1 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-acylglycerophosphocholine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-independent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peroxiredoxin activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within bleb assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular oxidant detoxification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycerophospholipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peroxiredoxin-6
    Names
    1-Cys PRX
    1-Cys peroxiredoxin
    LPC acyltransferase 5
    NSGPx
    acidic calcium-independent phospholipase A2
    aiPLA2
    antioxidant protein 2
    glutathione-dependent peroxiredoxin
    lyso-PC acyltransferase 5
    lysophosphatidylcholine acyltransferase 5
    non-selenium glutathione peroxidase
    thiol-specific antioxidant protein
    NP_446028.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053576.2NP_446028.1  peroxiredoxin-6

      See identical proteins and their annotated locations for NP_446028.1

      Status: PROVISIONAL

      Source sequence(s)
      AF014009
      UniProtKB/Swiss-Prot
      O35244
      UniProtKB/TrEMBL
      A0A8I5ZYW1, A6ID81
      Related
      ENSRNOP00000103996.1, ENSRNOT00000165363.1
      Conserved Domains (1) summary
      cd03016
      Location:7222
      PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      76062082..76072631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)