Il15 interleukin 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il15provided by RGD
Official Full Name: interleukin 15provided by RGD
Primary source: RGD:2887
See related: EnsemblRapid:ENSRNOG00000003439 AllianceGenome:RGD:2887
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine activity. Involved in several processes, including cellular response to vitamin D; negative regulation of smooth muscle cell proliferation; and skeletal muscle atrophy. Located in cell surface and extracellular space. Used to study pancreatitis. Biomarker of listeriosis and periodontal disease. Human ortholog(s) of this gene implicated in aspergillosis; asthma; pleurisy; and type 1 diabetes mellitus. Orthologous to human IL15 (interleukin 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 129.7), Muscle (RPKM 78.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (42536160..42611349)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (25640025..25706818)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (23542606..23624366, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of short-term physical training on the interleukin-15 signalling pathway and glucose tolerance in aged rats.
Title: Effects of short-term physical training on the interleukin-15 signalling pathway and glucose tolerance in aged rats.
These results support the hypothesis that IL-15 secreted from Gn-GC-C-expressing macrophages contributes to the inhibition of fatty acid synthase and lipid accumulation in adipocytes, leading to obesity resistance
Title: Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.
study indicates that training, skeletal muscle phenotype, and metabolic status all influence the temporal pattern of post-exercise changes in IL-15 expression.
Title: Time course of IL-15 expression after acute resistance exercise in trained rats: effect of diabetes and skeletal muscle phenotype.
found that in diabetic rats, resistance training increased muscle and serum IL-15 levels
Title: Expression of interleukin-15 and inflammatory cytokines in skeletal muscles of STZ-induced diabetic rats: effect of resistance exercise training.
results suggested that IL-15-Akt signaling harbored the complex signals for muscle-T cell interaction, the regulatory networks have significant potential for the restriction on IL-1beta inflammatory signaling
Title: Functional capability of IL-15-Akt signaling in the denervated muscle.
IL-15 is related to organ dysfunction during severe acute pancreatitis, and it functions as a protective factor against the organ injuries.
Title: Significant expression of interleukin 15 in rat experimental severe acute pancreatitis.
In early stage of acute rejection of renal allograft in rats, the expressions of osteopontin, IL15, perforin and granzyme B are up-regulated.
Title: [Expressions of interleukin-15 and osteopontin mRNA in early stage of acute rejection of renal allograft in rats].
The results of this study suggest that the IL-15 signal transduction pathway in neural cells is similar to that in immune cells.
Title: Effects of interleukin-15 on neuronal differentiation of neural stem cells.
Preservation of IL-15 signaling by calorie restriction may therefore represent a further mechanism contributing to the anti-aging effect of this dietary intervention in skeletal muscle
Title: Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction.
The changes observed in BAT suggest that IL-15 could be implicated in lipid consumption in this tissue by regulating lipid oxidation and probably thermogenesis, processes mediated by UCP1 and UCP3 and PPARdelta and PPARalpha.
Title: Effects of IL-15 on rat brown adipose tissue: uncoupling proteins and PPARs.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

D19Rat12 (e-PCR), detects polymorphism
- UniSTS:119555

RH127909 (e-PCR)
- UniSTS:211219

RH94635 (e-PCR)
- UniSTS:119882

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NK T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within NK T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	TAS Traceable Author Statement more info	PubMed
involved_in cell maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in extrathymic T cell selection	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extrathymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-15-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-15-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-15-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in lymph node development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lymph node development	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	IEA Inferred from Electronic Annotation more info
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neutrophil activation	IEA Inferred from Electronic Annotation more info
involved_in neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein O-linked glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein O-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein modification process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of defense response to virus by host	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle atrophy	IEP Inferred from Expression Pattern more info	PubMed
involved_in tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-15

Names: IL-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401135.1 → NP_001388064.1 interleukin-15 preproprotein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3
NM_013129.3 → NP_037261.1 interleukin-15 preproprotein

See identical proteins and their annotated locations for NP_037261.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3

Conserved Domains (1) summary

pfam02372
Location:33 → 154

IL15; Interleukin 15

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

42536160..42611349

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277819.1 → XP_063133889.1 interleukin-15 isoform X8

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3

Related

ENSRNOP00000004590.7, ENSRNOT00000004590.8
XM_063277812.1 → XP_063133882.1 interleukin-15 isoform X5
XM_063277811.1 → XP_063133881.1 interleukin-15 isoform X4
XM_063277821.1 → XP_063133891.1 interleukin-15 isoform X10
XM_063277813.1 → XP_063133883.1 interleukin-15 isoform X6
XM_063277820.1 → XP_063133890.1 interleukin-15 isoform X9
XM_039097507.2 → XP_038953435.1 interleukin-15 isoform X7
XM_063277804.1 → XP_063133874.1 interleukin-15 isoform X1
XM_063277806.1 → XP_063133876.1 interleukin-15 isoform X1
XM_063277808.1 → XP_063133878.1 interleukin-15 isoform X1
XM_063277807.1 → XP_063133877.1 interleukin-15 isoform X1
XM_063277805.1 → XP_063133875.1 interleukin-15 isoform X1
XM_063277810.1 → XP_063133880.1 interleukin-15 isoform X3
XM_063277822.1 → XP_063133892.1 interleukin-15 isoform X11

UniProtKB/TrEMBL

A0A8L2Q1M6
XM_039097509.2 → XP_038953437.1 interleukin-15 isoform X8

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3

Conserved Domains (1) summary

pfam02372
Location:33 → 154

IL15; Interleukin 15
XM_039097513.2 → XP_038953441.1 interleukin-15 isoform X8

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3

Conserved Domains (1) summary

pfam02372
Location:33 → 154

IL15; Interleukin 15
XM_039097515.2 → XP_038953443.1 interleukin-15 isoform X8

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3

Conserved Domains (1) summary

pfam02372
Location:33 → 154

IL15; Interleukin 15
XM_039097514.2 → XP_038953442.1 interleukin-15 isoform X8

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3

Conserved Domains (1) summary

pfam02372
Location:33 → 154

IL15; Interleukin 15
XM_039097517.2 → XP_038953445.1 interleukin-15 isoform X8

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3

Conserved Domains (1) summary

pfam02372
Location:33 → 154

IL15; Interleukin 15
XM_063277817.1 → XP_063133887.1 interleukin-15 isoform X8

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3
XM_063277814.1 → XP_063133884.1 interleukin-15 isoform X8

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3
XM_017601186.3 → XP_017456675.1 interleukin-15 isoform X8

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3

Conserved Domains (1) summary

pfam02372
Location:33 → 154

IL15; Interleukin 15
XM_063277809.1 → XP_063133879.1 interleukin-15 isoform X2
XM_063277815.1 → XP_063133885.1 interleukin-15 isoform X8

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3
XM_063277816.1 → XP_063133886.1 interleukin-15 isoform X8

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3

Related

ENSRNOP00000077234.1, ENSRNOT00000109879.2
XM_063277818.1 → XP_063133888.1 interleukin-15 isoform X8

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3
XM_039097511.2 → XP_038953439.1 interleukin-15 isoform X8

UniProtKB/Swiss-Prot

O54847, P97604

UniProtKB/TrEMBL

A0A8L2Q1M6, A6IYG3

Conserved Domains (1) summary

pfam02372
Location:33 → 154

IL15; Interleukin 15