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    Slc32a1 solute carrier family 32 member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83612, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc32a1provided by RGD
    Official Full Name
    solute carrier family 32 member 1provided by RGD
    Primary source
    RGD:621402
    See related
    EnsemblRapid:ENSRNOG00000015393 AllianceGenome:RGD:621402
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Vgat; Viaat; RUNC-47
    Summary
    Enables gamma-aminobutyric acid:proton antiporter activity and glycine transmembrane transporter activity. Involved in carboxylic acid transport; hippocampus development; and neurotransmitter loading into synaptic vesicle. Located in inhibitory synapse and synaptic vesicle. Is active in GABA-ergic synapse and synaptic vesicle membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy and generalized epilepsy with febrile seizures plus. Orthologous to human SLC32A1 (solute carrier family 32 member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 98.9) See more
    Orthologs
    NEW
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    Genomic context

    See Slc32a1 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (167687245..167691714)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (147267373..147271842)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (155102980..155107815)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101470 Neighboring gene uncharacterized LOC120101774 Neighboring gene actin related protein 5 Neighboring gene protein phosphatase 1, regulatory subunit 16B Neighboring gene 60S ribosomal protein L13-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in beta-alanine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gamma-aminobutyric acid import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gamma-aminobutyric acid import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gamma-aminobutyric acid import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in gamma-aminobutyric acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in gamma-aminobutyric acid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gamma-aminobutyric acid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycine transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glycine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glycine transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in hippocampus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in neurotransmitter loading into synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neurotransmitter loading into synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurotransmitter loading into synaptic vesicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell tip ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cone cell pedicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in inhibitory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in inhibitory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuron projection terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    vesicular inhibitory amino acid transporter
    Names
    GABA and glycine transporter
    UNC-47 homolog
    rGVAT
    solute carrier family 32 (GABA vesicular transporter), member 1
    vesicular GABA transporter
    vesicular inhibitory amino acid transporter-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031782.2NP_113970.1  vesicular inhibitory amino acid transporter

      See identical proteins and their annotated locations for NP_113970.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O35458
      UniProtKB/TrEMBL
      A6JWX5
      Related
      ENSRNOP00000020720.5, ENSRNOT00000020720.8
      Conserved Domains (1) summary
      pfam01490
      Location:115512
      Aa_trans; Transmembrane amino acid transporter protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      167687245..167691714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)