Stx7 syntaxin 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Stx7provided by RGD
Full Name: syntaxin 7provided by RGD
Primary source: RGD:619747
See related: EnsemblRapid:ENSRNOG00000015670 AllianceGenome:RGD:619747
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables SNAP receptor activity and SNARE binding activity. Involved in endosome to lysosome transport and vesicle fusion. Located in late endosome membrane and lysosomal membrane. Part of SNARE complex. Is active in synaptic vesicle membrane. Orthologous to human STX7 (syntaxin 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 292.5), Spleen (RPKM 242.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (23016330..23056579, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (21197075..21237320, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (22241655..22281850, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs
Title: Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IPI Inferred from Physical Interaction more info	PubMed
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables chloride channel inhibitor activity	IEA Inferred from Electronic Annotation more info
enables chloride channel inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables syntaxin binding	IEA Inferred from Electronic Annotation more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endosome to lysosome transport	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in organelle assembly	IEA Inferred from Electronic Annotation more info
involved_in organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in organelle localization	IEA Inferred from Electronic Annotation more info
involved_in organelle localization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor localization to synapse	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle exocytosis	TAS Traceable Author Statement more info	PubMed
involved_in synaptic vesicle to endosome fusion	ISO Inferred from Sequence Orthology more info
involved_in vesicle docking	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IDA Inferred from Direct Assay more info	PubMed
located_in azurophil granule	IEA Inferred from Electronic Annotation more info
located_in azurophil granule	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IEA Inferred from Electronic Annotation more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	EXP Inferred from Experiment more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	HDA more info	PubMed
located_in tertiary granule	IEA Inferred from Electronic Annotation more info
located_in tertiary granule	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: syntaxin-7

Names: syntaxin-7-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021869.2 → NP_068641.2 syntaxin-7

See identical proteins and their annotated locations for NP_068641.2

Status: PROVISIONAL

Source sequence(s)

BC085737

UniProtKB/Swiss-Prot

O70257, Q5U337

UniProtKB/TrEMBL

A0A0G2K6Y9, A6JUL4

Related

ENSRNOP00000021318.4, ENSRNOT00000021318.6

Conserved Domains (2) summary

cd15875
Location:168 → 227

SNARE_syntaxin7; SNARE motif of syntaxin 7

pfam14523
Location:18 → 119

Syntaxin_2; Syntaxin-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

23016330..23056579 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017589644.3 → XP_017445133.1 syntaxin-7 isoform X1

UniProtKB/Swiss-Prot

O70257, Q5U337

UniProtKB/TrEMBL

A0A0G2K6Y9, A6JUL4

Conserved Domains (2) summary

cd15875
Location:168 → 227

SNARE_syntaxin7; SNARE motif of syntaxin 7

pfam14523
Location:18 → 119

Syntaxin_2; Syntaxin-like protein
XM_039089032.2 → XP_038944960.1 syntaxin-7 isoform X1

UniProtKB/Swiss-Prot

O70257, Q5U337

UniProtKB/TrEMBL

A0A0G2K6Y9, A6JUL4

Conserved Domains (2) summary

cd15875
Location:168 → 227

SNARE_syntaxin7; SNARE motif of syntaxin 7

pfam14523
Location:18 → 119

Syntaxin_2; Syntaxin-like protein