Exoc8 exocyst complex component 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Exoc8provided by RGD
Official Full Name: exocyst complex component 8provided by RGD
Primary source: RGD:620245
See related: EnsemblRapid:ENSRNOG00000071599 AllianceGenome:RGD:620245
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Exo84
Summary: Predicted to enable phosphatidylinositol binding activity and small GTPase binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; endosome organization; and extracellular matrix disassembly. Predicted to act upstream of or within exocytosis. Located in cell leading edge. Part of exocyst. Orthologous to human EXOC8 (exocyst complex component 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (69752387..69754876, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (52855010..52857499, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (57647305..57649794, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exocytosis	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	TAS Traceable Author Statement more info	PubMed
involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	IDA Inferred from Direct Assay more info	PubMed
part_of exocyst	ISO Inferred from Sequence Orthology more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: exocyst complex component 8

Names: exocyst complex 84 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139043.2 → NP_620612.1 exocyst complex component 8

See identical proteins and their annotated locations for NP_620612.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

O54924

UniProtKB/TrEMBL

A6KJ24

Related

ENSRNOP00000026757.1, ENSRNOT00000026757.5

Conserved Domains (4) summary

cd01226
Location:167 → 279

PH_RalBD_exo84; Exocyst complex 84-kDa subunit Ral-binding domain/Pleckstrin Homology (PH) domain

pfam00169
Location:174 → 273

PH; PH domain

pfam08700
Location:13 → 97

Vps51; Vps51/Vps67

pfam16528
Location:326 → 531

Exo84_C; Exocyst component 84 C-terminal