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    Pdp1 pyruvate dehydrogenase phosphatase catalytic subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54705, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pdp1provided by RGD
    Official Full Name
    pyruvate dehydrogenase phosphatase catalytic subunit 1provided by RGD
    Primary source
    RGD:620393
    See related
    EnsemblRapid:ENSRNOG00000016180 AllianceGenome:RGD:620393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ppm2c; PDPC 1
    Summary
    Enables calcium ion binding activity; magnesium ion binding activity; and protein serine/threonine phosphatase activity. Predicted to be involved in peptidyl-threonine dephosphorylation and signal transduction. Located in mitochondrion. Human ortholog(s) of this gene implicated in obesity and pyruvate decarboxylase deficiency. Orthologous to human PDP1 (pyruvate dehydrogenase phosphatase catalytic subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 371.6), Heart (RPKM 325.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pdp1 in Genome Data Viewer
    Location:
    5q13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (30245699..30252494, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (25446843..25455107, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (25577593..25584325, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene GTP binding protein overexpressed in skeletal muscle Neighboring gene cadherin 17 Neighboring gene uncharacterized LOC102552377 Neighboring gene uncharacterized LOC134478935 Neighboring gene transmembrane protein 67

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in peptidyl-threonine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial
    Names
    protein phosphatase 2C, magnesium dependent, catalytic subunit
    pyruvate dehydrogenase phosphatase isoenzyme 1
    pyruvate dehyrogenase phosphatase catalytic subunit 1
    NP_001258037.1
    NP_062245.2
    XP_006237969.2
    XP_006237970.1
    XP_006237971.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271108.3NP_001258037.1  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001258037.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2JWE0, A0A0G2QC17, A6II75
      Related
      ENSRNOP00000062054.3, ENSRNOT00000067823.5
      Conserved Domains (1) summary
      cd00143
      Location:134550
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    2. NM_001429757.1NP_001416686.1  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2JWE0, A6II74
    3. NM_001429758.1NP_001416687.1  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2JWE0, A0A0G2QC17, A6II75
    4. NM_001429759.1NP_001416688.1  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      A1L1J4, F1LP63, O88483
      UniProtKB/TrEMBL
      A0A0G2JWE0, A0A0G2JY56
    5. NM_019372.5NP_062245.2  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_062245.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      A1L1J4, F1LP63, O88483
      UniProtKB/TrEMBL
      A0A0G2JWE0, A0A0G2JY56
      Related
      ENSRNOP00000070525.2, ENSRNOT00000090376.3
      Conserved Domains (1) summary
      cd00143
      Location:109525
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      30245699..30252494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237909.5XP_006237971.1  pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd00143
      Location:134550
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    2. XM_006237908.4XP_006237970.1  pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A0G2JWE0
      Related
      ENSRNOP00000108417.1, ENSRNOT00000134828.1
      Conserved Domains (1) summary
      cd00143
      Location:149565
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    3. XM_006237907.5XP_006237969.2  pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial isoform X1

      Related
      ENSRNOP00000069844.2, ENSRNOT00000090579.3
      Conserved Domains (1) summary
      cd00143
      Location:145561
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...