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    Ctbp1 C-terminal binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29382, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ctbp1provided by RGD
    Official Full Name
    C-terminal binding protein 1provided by RGD
    Primary source
    RGD:2441
    See related
    EnsemblRapid:ENSRNOG00000005428 AllianceGenome:RGD:2441
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bars; BARS-50; CtBP3/BARS; 50-kDaBFA-inducedADP-ribosylatedsubstrate
    Summary
    Enables NAD binding activity; PDZ domain binding activity; and protein homodimerization activity. Involved in presynapse to nucleus signaling pathway. Located in cytoplasm and nucleus. Is active in glutamatergic synapse. Is extrinsic component of presynaptic endocytic zone membrane. Orthologous to human CTBP1 (C-terminal binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 462.1), Muscle (RPKM 461.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ctbp1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (81679956..81707331)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (77455580..77482821)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (82762109..82789350)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481860 Neighboring gene macrophage erythroblast attacher, E3 ubiquitin ligase Neighboring gene uncharacterized LOC134481861 Neighboring gene spondin 2 Neighboring gene solute carrier family 5 member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC93318

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coregulator binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transcription corepressor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in membrane fusion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in presynapse to nucleus signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in presynapse to nucleus signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic vesicle clustering IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic vesicle clustering ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in white fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in white fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in white fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in extrinsic component of presynaptic endocytic zone membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynaptic active zone cytoplasmic component IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic active zone cytoplasmic component ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription repressor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription repressor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    C-terminal-binding protein 1
    Names
    50 kDa BFA-dependent ADP-ribosylation substrate
    50-kDa BFA-induced ADP-ribosylated substrate
    C-terminal-binding protein 3
    C-terminus binding protein 3/brefeldin A (BFA) adenosine diphosphate-ribosylated substrate
    brefeldin A-ADP-riboslyated substrate
    ctBP3
    NP_062074.2
    XP_006251287.1
    XP_006251288.1
    XP_006251289.1
    XP_006251290.1
    XP_017454636.1
    XP_063129063.1
    XP_063129064.1
    XP_063129066.1
    XP_063129067.1
    XP_063129068.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019201.3NP_062074.2  C-terminal-binding protein 1

      See identical proteins and their annotated locations for NP_062074.2

      Status: PROVISIONAL

      Source sequence(s)
      AF067795
      UniProtKB/Swiss-Prot
      Q9Z2F5
      UniProtKB/TrEMBL
      A0A8I5ZSG1, A6IK67
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      81679956..81707331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251225.5XP_006251287.1  C-terminal-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UI20, A0A8I5ZSG1
      Related
      ENSRNOP00000054738.5, ENSRNOT00000057929.6
      Conserved Domains (1) summary
      cd05299
      Location:28346
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    2. XM_006251227.5XP_006251289.1  C-terminal-binding protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZSG1
      Conserved Domains (1) summary
      cd05299
      Location:28346
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    3. XM_006251226.5XP_006251288.1  C-terminal-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZSG1
      Conserved Domains (1) summary
      cd05299
      Location:28346
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    4. XM_006251228.5XP_006251290.1  C-terminal-binding protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZSG1
      Conserved Domains (1) summary
      cd05299
      Location:28346
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    5. XM_017599147.3XP_017454636.1  C-terminal-binding protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q9Z2F5
      UniProtKB/TrEMBL
      A0A8I5ZSG1, A6IK67
      Conserved Domains (1) summary
      cd05299
      Location:17335
      CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
    6. XM_063272994.1XP_063129064.1  C-terminal-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZSG1
    7. XM_063272998.1XP_063129068.1  C-terminal-binding protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZSG1, Q6AZ26
    8. XM_063272997.1XP_063129067.1  C-terminal-binding protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZSG1, F7FG31
      Related
      ENSRNOP00000080240.2, ENSRNOT00000112665.2
    9. XM_063272993.1XP_063129063.1  C-terminal-binding protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q9Z2F5
      UniProtKB/TrEMBL
      A0A8I5ZSG1, A6IK67
    10. XM_063272996.1XP_063129066.1  C-terminal-binding protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZSG1
      Related
      ENSRNOP00000081185.2, ENSRNOT00000119292.2