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    Akap1 A-kinase anchoring protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114124, updated on 2-Nov-2024

    Summary

    Official Symbol
    Akap1provided by RGD
    Official Full Name
    A-kinase anchoring protein 1provided by RGD
    Primary source
    RGD:620826
    See related
    EnsemblRapid:ENSRNOG00000002373 AllianceGenome:RGD:620826
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Akap84
    Summary
    Enables several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and tubulin binding activity. Involved in several processes, including cellular response to cAMP; negative regulation of cell growth involved in cardiac muscle cell development; and negative regulation of protein import into nucleus. Located in lipid droplet; mitochondrial crista; and postsynaptic membrane. Is active in neuromuscular junction and postsynaptic specialization, intracellular component. Biomarker of brain ischemia. Orthologous to human AKAP1 (A-kinase anchoring protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 364.2), Testes (RPKM 254.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Akap1 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (74118232..74151366, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (73621021..73654123, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (76151013..76183987, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene musashi RNA-binding protein 2 Neighboring gene uncharacterized LOC134480853 Neighboring gene uncharacterized LOC134480854 Neighboring gene uncharacterized LOC134480855 Neighboring gene U6 spliceosomal RNA Neighboring gene NADH:ubiquinone oxidoreductase subunit A13, pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase A regulatory subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase A regulatory subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial crista IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic specialization, intracellular component IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    A-kinase anchor protein 1, mitochondrial
    Names
    A kinase (PRKA) anchor protein 1
    A-kinase anchor protein 121 kDa
    AKAP 121
    D-AKAP-1
    PRKA1
    S-AKAP84
    a kinase anchor protein 1, mitochondrial
    dual specificity A-kinase-anchoring protein 1
    protein kinase A-anchoring protein 1
    spermatid A-kinase anchor protein 84

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053665.1NP_446117.1  A-kinase anchor protein 1, mitochondrial

      See identical proteins and their annotated locations for NP_446117.1

      Status: PROVISIONAL

      Source sequence(s)
      AF068202
      UniProtKB/Swiss-Prot
      O88884, O88980
      Conserved Domains (4) summary
      smart00333
      Location:707765
      TUDOR; Tudor domain
      cd00105
      Location:562622
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:655777
      TUDOR; Tudor domain
      pfam04814
      Location:394510
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      74118232..74151366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247068.3XP_006247130.1  A-kinase anchor protein 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006247130.1

      UniProtKB/TrEMBL
      A6HHY7, F1LMK0
      Conserved Domains (4) summary
      smart00333
      Location:707765
      TUDOR; Tudor domain
      cd00105
      Location:562622
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:655777
      TUDOR; Tudor domain
      pfam04814
      Location:394510
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
    2. XM_063268270.1XP_063124340.1  A-kinase anchor protein 1, mitochondrial isoform X4

    3. XM_006247067.5XP_006247129.1  A-kinase anchor protein 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006247129.1

      UniProtKB/TrEMBL
      A6HHY7, F1LMK0
      Conserved Domains (4) summary
      smart00333
      Location:707765
      TUDOR; Tudor domain
      cd00105
      Location:562622
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:655777
      TUDOR; Tudor domain
      pfam04814
      Location:394510
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
    4. XM_063268268.1XP_063124338.1  A-kinase anchor protein 1, mitochondrial isoform X4

    5. XM_008767930.3XP_008766152.1  A-kinase anchor protein 1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_008766152.1

      UniProtKB/TrEMBL
      A6HHY7, F1LMK0
      Related
      ENSRNOP00000052543.5, ENSRNOT00000055683.7
      Conserved Domains (4) summary
      smart00333
      Location:707765
      TUDOR; Tudor domain
      cd00105
      Location:562622
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00567
      Location:655777
      TUDOR; Tudor domain
      pfam04814
      Location:394510
      HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus
    6. XM_063268271.1XP_063124341.1  A-kinase anchor protein 1, mitochondrial isoform X5

    7. XM_063268272.1XP_063124342.1  A-kinase anchor protein 1, mitochondrial isoform X5

    8. XM_039085023.2XP_038940951.1  A-kinase anchor protein 1, mitochondrial isoform X2

      Conserved Domains (2) summary
      PHA03307
      Location:336498
      PHA03307; transcriptional regulator ICP4; Provisional
      cd22395
      Location:560609
      KH-I_AKAP1; type I K homology (KH) RNA-binding domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins
    9. XM_039085025.2XP_038940953.1  A-kinase anchor protein 1, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6HHY9, D4A9M6
      Related
      ENSRNOP00000003251.7, ENSRNOT00000003251.9
      Conserved Domains (1) summary
      NF033201
      Location:279490
      Vip_LPXTG_Lm; cell invasion LPXTG protein Vip

    RNA

    1. XR_005489677.2 RNA Sequence

    2. XR_005489675.2 RNA Sequence

    3. XR_005489674.2 RNA Sequence

    4. XR_005489676.2 RNA Sequence