U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ptpn23 protein tyrosine phosphatase, non-receptor type 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117552, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ptpn23provided by RGD
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 23provided by RGD
    Primary source
    RGD:619892
    See related
    EnsemblRapid:ENSRNOG00000020862 AllianceGenome:RGD:619892
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    HD-PTP; Ptp-Td14
    Summary
    Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including endosomal transport; positive regulation of adherens junction organization; and positive regulation of transport. Predicted to be located in ciliary basal body; early endosome; and nuclear body. Predicted to be active in endosome. Orthologous to human PTPN23 (protein tyrosine phosphatase non-receptor type 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 56.4), Kidney (RPKM 45.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ptpn23 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119239213..119261675, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110360804..110383271, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (118628777..118651238, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 6 Neighboring gene SREBF chaperone Neighboring gene kelch-like family member 18 Neighboring gene neutrophilic granule protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in early endosome to late endosome transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytic recycling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Wnt protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of Wnt protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of adherens junction organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of adherens junction organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of early endosome to late endosome transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of homophilic cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of homophilic cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 23
    Names
    his domain-containing protein tyrosine phosphatase
    protein tyrosine phosphatase TD14
    NP_476552.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057204.2NP_476552.2  tyrosine-protein phosphatase non-receptor type 23

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      O88902, Q9QZP8
      UniProtKB/TrEMBL
      F1M951
      Related
      ENSRNOP00000052992.1, ENSRNOT00000056145.4
      Conserved Domains (5) summary
      cd09234
      Location:362702
      V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
      cd09239
      Location:2357
      BRO1_HD-PTP_like; Protein-interacting, N-terminal, Bro1-like domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
      cd00047
      Location:12501479
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      pfam00102
      Location:12501480
      Y_phosphatase; Protein-tyrosine phosphatase
      pfam13949
      Location:417703
      ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      119239213..119261675 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)