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    Adgrl1 adhesion G protein-coupled receptor L1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65096, updated on 3-Dec-2024

    Summary

    Official Symbol
    Adgrl1provided by RGD
    Official Full Name
    adhesion G protein-coupled receptor L1provided by RGD
    Primary source
    RGD:620768
    See related
    EnsemblRapid:ENSRNOG00000029134 AllianceGenome:RGD:620768
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CL1BA; Lphn1
    Summary
    Enables cell adhesion molecule binding activity; toxic substance binding activity; and transmembrane signaling receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within positive regulation of synapse assembly. Located in growth cone; plasma membrane; and synapse. Is active in glutamatergic synapse and presynaptic membrane. Orthologous to human ADGRL1 (adhesion G protein-coupled receptor L1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 198.5), Kidney (RPKM 133.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Adgrl1 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41107162..41148752, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24202405..24244137, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25029037..25069146)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene protein kinase cAMP-activated catalytic subunit alpha Neighboring gene uncharacterized LOC120098559 Neighboring gene anti-silencing function 1B histone chaperone Neighboring gene uncharacterized LOC120098560 Neighboring gene uncharacterized LOC134483330 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134483629

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cell adhesion molecule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables latrotoxin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables latrotoxin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables toxic substance binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor L1
    Names
    CIRL-1
    calcium-independent alpha-latrotoxin receptor 1
    latrophilin-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431366.1NP_001418295.1  adhesion G protein-coupled receptor L1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6AG63, A6IYC5
    2. NM_022962.2NP_075251.1  adhesion G protein-coupled receptor L1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_075251.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6AG63
      Related
      ENSRNOP00000043269.4, ENSRNOT00000045699.6
      Conserved Domains (7) summary
      smart00303
      Location:797849
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:476539
      HormR; Domain present in hormone receptors
      pfam00002
      Location:8571092
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam02140
      Location:48128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:11121471
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:550771
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:142398
      OLF; Olfactomedin-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      41107162..41148752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097967.2XP_038953895.1  adhesion G protein-coupled receptor L1 isoform X4

      Conserved Domains (8) summary
      smart00303
      Location:792844
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:471534
      HormR; Domain present in hormone receptors
      PHA03247
      Location:393477
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:8511108
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:11071466
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:544768
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:137393
      OLF; Olfactomedin-like domain
    2. XM_039097965.2XP_038953893.1  adhesion G protein-coupled receptor L1 isoform X2

      Conserved Domains (8) summary
      smart00303
      Location:792844
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:471534
      HormR; Domain present in hormone receptors
      PHA03247
      Location:393477
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:8511108
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:11071511
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:544768
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:137393
      OLF; Olfactomedin-like domain
    3. XM_039097964.2XP_038953892.1  adhesion G protein-coupled receptor L1 isoform X1

      Related
      ENSRNOP00000086387.2, ENSRNOT00000103294.2
      Conserved Domains (8) summary
      smart00303
      Location:797849
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:476539
      HormR; Domain present in hormone receptors
      PHA03247
      Location:398482
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:8561113
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:11121516
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:549773
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:142398
      OLF; Olfactomedin-like domain
    4. XM_039097966.2XP_038953894.1  adhesion G protein-coupled receptor L1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AG63
      Conserved Domains (8) summary
      smart00303
      Location:798850
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:477540
      HormR; Domain present in hormone receptors
      PHA03247
      Location:399483
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:8571114
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02140
      Location:48128
      Gal_Lectin; Galactose binding lectin domain
      pfam02354
      Location:11131472
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:550774
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:143399
      OLF; Olfactomedin-like domain
    5. XM_039097969.2XP_038953897.1  adhesion G protein-coupled receptor L1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6G3M0
      Related
      ENSRNOP00000091684.2, ENSRNOT00000098082.2
      Conserved Domains (7) summary
      smart00303
      Location:694746
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:373436
      HormR; Domain present in hormone receptors
      PHA03247
      Location:295379
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:7531010
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:10091368
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:446670
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:39295
      OLF; Olfactomedin-like domain
    6. XM_039097968.2XP_038953896.1  adhesion G protein-coupled receptor L1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6G3M0
      Conserved Domains (7) summary
      smart00303
      Location:699751
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:378441
      HormR; Domain present in hormone receptors
      PHA03247
      Location:300384
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:7581015
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:10141373
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:451675
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:44300
      OLF; Olfactomedin-like domain
    7. XM_039097971.2XP_038953899.1  adhesion G protein-coupled receptor L1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AB35, A0A8I6G3M0, A6IYC7
      Related
      ENSRNOP00000079689.2, ENSRNOT00000115789.2
      Conserved Domains (7) summary
      smart00303
      Location:621673
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:300363
      HormR; Domain present in hormone receptors
      PHA03247
      Location:222306
      PHA03247; large tegument protein UL36; Provisional
      cd16007
      Location:680937
      7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      pfam02354
      Location:9361295
      Latrophilin; Latrophilin Cytoplasmic C-terminal region
      pfam16489
      Location:373597
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl02549
      Location:1222
      OLF; Olfactomedin-like domain
    8. XM_063278273.1XP_063134343.1  adhesion G protein-coupled receptor L1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AB35, A0A8I6G3M0, A6IYC7