Cngb1 cyclic nucleotide gated channel subunit beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cngb1provided by RGD
Official Full Name: cyclic nucleotide gated channel subunit beta 1provided by RGD
Primary source: RGD:621809
See related: EnsemblRapid:ENSRNOG00000031773 AllianceGenome:RGD:621809
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CNG4; CNG-4; Gm1959
Summary: Enables cyclic nucleotide binding activity and intracellularly cyclic nucleotide-activated monoatomic cation channel activity. Involved in metal ion transport and regulation of cytosolic calcium ion concentration. Located in non-motile cilium membrane and terminal bouton. Part of intracellular cyclic nucleotide activated cation channel complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 45. Orthologous to human CNGB1 (cyclic nucleotide gated channel subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 3.0), Spleen (RPKM 0.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p13

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (9732646..9798864)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (9726595..9791111)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (10142440..10206618)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CNGB1b subunit participates in ligand-gated activation of olfactory CNG channels and, particularly, contributes to rapid termination of odorant signal in an olfactory sensory neuron.
Title: Deciphering the function of the CNGB1b subunit in olfactory CNG channels.

Submit: New GeneRIF Correction

General gene information

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Markers

RH138953 (e-PCR)
- UniSTS:221039

PMC26527P1 (e-PCR)
- UniSTS:272340

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cAMP binding	IDA Inferred from Direct Assay more info	PubMed
enables cAMP binding	ISO Inferred from Sequence Orthology more info
enables cGMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cGMP binding	IDA Inferred from Direct Assay more info	PubMed
enables cGMP binding	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables cyclic nucleotide-activated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly cAMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cAMP-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly cAMP-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly cGMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cGMP-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly cGMP-activated cation channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity	TAS Traceable Author Statement more info	PubMed
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of light stimulus involved in visual perception	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within photoreceptor cell maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within photoreceptor cell outer segment organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phototransduction	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization to organelle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in retina homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in retina homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of smell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of smell	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in visual perception	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of intracellular cyclic nucleotide activated cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of intracellular cyclic nucleotide activated cation channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in non-motile cilium membrane	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in rod photoreceptor outer segment	ISS Inferred from Sequence or Structural Similarity more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
part_of transmembrane transporter complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclic nucleotide-gated channel beta-1; cyclic nucleotide-gated cation channel beta-1

Names: CNG channel 4; cyclic nucleotide gated channel beta 1; cyclic nucleotide-gated cation channel 4; cyclic nucleotide-gated channel beta subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001389260.1 → NP_001376189.1 cyclic nucleotide-gated channel beta-1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

O55150
NM_031809.2 → NP_113997.2 cyclic nucleotide-gated channel beta-1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

O35788

Related

ENSRNOP00000079558.2, ENSRNOT00000109711.2

Conserved Domains (2) summary

PLN03192
Location:743 → 1129

PLN03192; Voltage-dependent potassium channel; Provisional

cd00038
Location:1057 → 1166

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...