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    Slc5a3 solute carrier family 5 member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114507, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc5a3provided by RGD
    Official Full Name
    solute carrier family 5 member 3provided by RGD
    Primary source
    RGD:621530
    See related
    EnsemblRapid:ENSRNOG00000067988 AllianceGenome:RGD:621530
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Smit
    Summary
    Predicted to enable several functions, including monosaccharide transmembrane transporter activity; myo-inositol:sodium symporter activity; and transmembrane transporter binding activity. Predicted to be involved in monosaccharide transmembrane transport; polyol transmembrane transport; and regulation of transporter activity. Predicted to act upstream of or within several processes, including inositol metabolic process; myo-inositol transport; and positive regulation of reactive oxygen species biosynthetic process. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and perinuclear region of cytoplasm. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human SLC5A3 (solute carrier family 5 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Slc5a3 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44799787..44802233)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (31313847..31316293)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (32229366..32231812)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095621 Neighboring gene uncharacterized LOC120095620 Neighboring gene mitochondrial ribosomal protein S6 Neighboring gene uncharacterized LOC103693540 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC102548079

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-glucose:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables D-glucose:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables D-glucose:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables myo-inositol:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pentose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables polyol transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fucose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hexose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within inositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myo-inositol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within myo-inositol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myo-inositol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pentose transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peripheral nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in polyol transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein localization to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of respiratory gaseous exchange ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sodium/myo-inositol cotransporter
    Names
    solute carrier family 5 (inositol transporters), member 3
    solute carrier family 5 (sodium/myo-inositol cotransporter), member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053715.2NP_446167.2  sodium/myo-inositol cotransporter

      See identical proteins and their annotated locations for NP_446167.2

      Status: VALIDATED

      Source sequence(s)
      AY231162, BE116021, CA513484
      UniProtKB/TrEMBL
      A0A8I6GM79, A6JLI6, Q80WA5
      Related
      ENSRNOP00000106713.1, ENSRNOT00000150252.1
      Conserved Domains (1) summary
      cd11491
      Location:9718
      SLC5sbd_SMIT; Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      44799787..44802233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)