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    Tmed10 transmembrane p24 trafficking protein 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84599, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmed10provided by RGD
    Official Full Name
    transmembrane p24 trafficking protein 10provided by RGD
    Primary source
    RGD:620970
    See related
    EnsemblRapid:ENSRNOG00000007901 AllianceGenome:RGD:620970
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmp21
    Summary
    Predicted to enable protein transmembrane transporter activity and syntaxin binding activity. Involved in several processes, including Golgi organization; response to alkaloid; and vesicle targeting, to, from or within Golgi. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and endoplasmic reticulum-Golgi intermediate compartment. Part of gamma-secretase complex. Orthologous to human TMED10 (transmembrane p24 trafficking protein 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 658.1), Kidney (RPKM 657.8) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tmed10 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110722887..110757743, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104991843..105026705, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (109169739..109205004, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene zinc finger, C2HC-type containing 1C Neighboring gene NIMA-related kinase 9 Neighboring gene uncharacterized LOC102549675 Neighboring gene uncharacterized LOC134479451 Neighboring gene uncharacterized LOC120103578 Neighboring gene 40S ribosomal protein S28 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in COPI-coated vesicle budding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in COPI-coated vesicle budding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in COPI-coated vesicle budding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Golgi organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytosol to ERGIC protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytosol to ERGIC protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytosol to ERGIC protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular protein transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intracellular protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in kidney development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-1 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-1 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-1 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to ERGIC IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to ERGIC ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to ERGIC ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulated exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulated exocytosis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of amyloid-beta formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of amyloid-beta formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to alkaloid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vesicle targeting NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in vesicle targeting, to, from or within Golgi IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in vesicle targeting, to, from or within Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in COPI-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in COPI-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of gamma-secretase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of gamma-secretase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of gamma-secretase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in trans-Golgi network transport vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in zymogen granule membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in zymogen granule membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in zymogen granule membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transmembrane emp24 domain-containing protein 10
    Names
    21 kDa transmembrane-trafficking protein
    integral membrane protein Tmp21-I (p23)
    p24 family protein delta-1
    p24delta1
    transmembrane emp24-like trafficking protein 10
    transmembrane protein Tmp21
    transmembrane trafficking protein 21

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053467.1NP_445919.1  transmembrane emp24 domain-containing protein 10 precursor

      See identical proteins and their annotated locations for NP_445919.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ004912
      UniProtKB/Swiss-Prot
      Q63584, Q9R0W6
      UniProtKB/TrEMBL
      A0A8L2Q4S6, A6JE25
      Related
      ENSRNOP00000010512.7, ENSRNOT00000010512.8
      Conserved Domains (1) summary
      pfam01105
      Location:31213
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      110722887..110757743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)