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    Coro1b coronin 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29474, updated on 27-Nov-2024

    Summary

    Official Symbol
    Coro1bprovided by RGD
    Official Full Name
    coronin 1Bprovided by RGD
    Primary source
    RGD:2382
    See related
    EnsemblRapid:ENSRNOG00000021828 AllianceGenome:RGD:2382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables Arp2/3 complex binding activity and cytoskeletal protein binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; negative regulation of lamellipodium morphogenesis; and negative regulation of smooth muscle cell chemotaxis. Located in several cellular components, including lamellipodium; perinuclear region of cytoplasm; and stress fiber. Orthologous to human CORO1B (coronin 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 969.2), Thymus (RPKM 664.6) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Coro1b in Genome Data Viewer
    Location:
    1q43
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210872437..210877876)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201442977..201448416)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219397827..219403253)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene calcium binding protein 4 Neighboring gene G protein-coupled receptor 152 Neighboring gene ribosomal protein L35A, pseudogene 6 Neighboring gene protein tyrosine phosphatase, receptor type, C-associated protein Neighboring gene ribosomal protein S6 kinase B2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Arp2/3 complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Arp2/3 complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament branching IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament branching ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to platelet-derived growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to platelet-derived growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lamellipodium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of smooth muscle cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cell leading edge IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in ruffle organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ruffle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in actin filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    coronin-1B
    Names
    coronin, actin-binding protein, 1B
    coronin-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019222.2NP_062095.2  coronin-1B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O89046
      UniProtKB/TrEMBL
      A6HYU3, G3V940
      Related
      ENSRNOP00000081471.2, ENSRNOT00000094725.2
      Conserved Domains (2) summary
      sd00039
      Location:3880
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10480
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210872437..210877876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230774.5XP_006230836.1  coronin-1B isoform X1

      See identical proteins and their annotated locations for XP_006230836.1

      UniProtKB/Swiss-Prot
      O89046
      UniProtKB/TrEMBL
      A6HYU3, G3V940
      Conserved Domains (2) summary
      sd00039
      Location:3880
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10480
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006230773.4XP_006230835.1  coronin-1B isoform X1

      See identical proteins and their annotated locations for XP_006230835.1

      UniProtKB/Swiss-Prot
      O89046
      UniProtKB/TrEMBL
      A6HYU3, G3V940
      Conserved Domains (2) summary
      sd00039
      Location:3880
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10480
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...