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    Ces1c carboxylesterase 1C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24346, updated on 9-Dec-2024

    Summary

    Symbol
    Ces1cprovided by RGD
    Full Name
    carboxylesterase 1Cprovided by RGD
    Primary source
    RGD:2571
    See related
    EnsemblRapid:ENSRNOG00000069004 AllianceGenome:RGD:2571
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Es1; Es2
    Summary
    Enables carboxylesterase activity and protein homodimerization activity. Predicted to be involved in lipid catabolic process. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum and lipid droplet. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1) and CES1P1 (carboxylesterase 1 pseudogene 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 1471.6) See more
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    Genomic context

    See Ces1c in Genome Data Viewer
    Location:
    19p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (30099383..30128531)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (13926401..13955527)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (15294524..15335005)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carboxylesterase 1E Neighboring gene carboxylesterase 1D Neighboring gene uncharacterized LOC134483613 Neighboring gene carboxylesterase 1A Neighboring gene solute carrier family 6 member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Clone Names

    • MGC109055

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    carboxylesterase 1C
    Names
    E1
    ES-THET
    Esterase 2 member of carboxylesterase-cluster 1
    NREH
    REH
    carboxyesterase ES-1
    esterase 1
    esterase 2, member of carboxylesterase-cluster 1
    esterase-2
    liver carboxylesterase 1
    microsomal carboxyesterase E1-like
    neutral retinyl ester hydrolase
    retinyl ester hydrolase
    NP_058700.1
    XP_006255234.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017004.1NP_058700.1  carboxylesterase 1C precursor

      See identical proteins and their annotated locations for NP_058700.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088251
      UniProtKB/Swiss-Prot
      P10959, Q5I0K0, Q63106, Q64626
      Related
      ENSRNOP00000024622.9, ENSRNOT00000024622.9
      Conserved Domains (1) summary
      pfam00135
      Location:24532
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      30099383..30128531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255172.5XP_006255234.2  carboxylesterase 1C isoform X1

      UniProtKB/Swiss-Prot
      P10959, Q5I0K0, Q63106, Q64626
      Conserved Domains (1) summary
      pfam00135
      Location:24534
      COesterase; Carboxylesterase family